Improving the management of blood pressure in acute stroke: the Efficacy of Nitric Oxide in Stroke (ENOS) trial

一氧化氮在中风中的疗效（ENOS）试验研究了中风后48小时内治疗高血压的方法。许多患者在中风后立即出现高血压，我们知道这些人比血压正常的患者更容易死亡或残疾。目前，医生通常不会在中风后立即治疗高血压，因此这项试验调查降低血压是否有助于患者康复。我们正在使用一种行之有效的药物，叫做三硝酸甘油（GTN），它可以放松血管，降低血压。该试验将招募5000名患者，并将接受GTN治疗7天的患者与未接受GTN治疗的患者进行比较。该试验还检查了患者是否应该停止或继续治疗7天。患者在90天内通过电话随访。主要结果是比较中风后死亡或残疾到无法自理的患者人数。ENOS是一项国际试验，目前有52个中心在13个国家招募患者。该试验由MRC资助，直到2011年11月。诺丁汉大学是赞助商。

The Efficacy of Nitric Oxide in Stroke (ENOS) Trial examines treating high blood pressure within 48 hours of stroke. Many patients have high blood pressure immediately after a stroke and we know that these people are more likely to die or be disabled than patients with normal blood pressure. At present, doctors do not usually treat high blood pressure immediately after a stroke so this trial investigates whether or not lowering blood pressure helps people to recover. We are using a well-established medication called glyceryl trinitrate (GTN) which relaxes blood vessels to lower blood pressure. The trial will recruit 5,000 patients and compares patients treated with GTN for 7 days against patients who do not receive GTN. The trial also examines whether or not patients blood pressure treatment should stop or continue for 7 days. Patients are followed up by telephone call at 90 days. The main outcome is comparison of the number of patients who have died or are too disabled to care for themselves after their stroke. ENOS is an international trial with 52 current centres recruiting patients across 13 countries. The trial is funded by the MRC until November 2011. The University of Nottingham is the sponsor.