Core C: Animal Models

核心C（动物模型核心）的总体目标是支持动物模型的开发和使用 在这个项目的资助（PPG）。动物模型核心的指导原则是 有效规划和利用动物，标准化处理和诊断，服务可靠性 和动物模型的一致性评价，并成为所有动物成本的成本中心。根本 中心提供的专业知识包括实验动物医学和临床及解剖病理学。的 核心在兽医生物科学系中安置和协调。Stefan Niewiesk博士，提议 核心主任自2004年以来一直是动物核心的联合主任，是所有动物中心的积极合作者。 PPG的主要研究者。他是兽医微生物学和实验动物认证 兽医（欧洲）由于Niewiesk博士的独特培训，他还提供专业知识， 为PPG的特定项目生成单克隆和多克隆抗体。托马斯·罗索尔博士 （项目4，Co-Pi），谁是由美国兽医病理学家学院认证将担任共同主任 为了核心这些调查人员由经验丰富的技术人员组成， 专业团队指导核心并实现PPG研究者的目标。一个共同的线索， 所有研究小组都共享使用了HTLV-1和HTLV-2的独特感染性分子克隆， 在我们的实验室开发或表征，并链接到已建立的动物模型，以测试分子 疾病的决定因素。自2003年以来，研究人员进一步发展了多个新的相互依存的 方法，技术和协同交流，有助于整合他们的科学，以接近基本的 生物范例作为项目实验室的预期成果。高度互动的动物核心 在Niewiesk博士的指导下，将提供一种中央采购和采购方法，以促进动物 研究，并减少重复和促进项目之间的合作。的独特作用 动物核心将为教师提供小鼠病理学方面的专业知识，并提供最先进的 确定和量化骨病变的方法。

The overall goal of Core C (Animal Model Core) is to support the development and use of the animal models employed within this Program Project Grant (PPG). The guiding principals for the animal model core are efficient planning and utilization of animals, standardization of processing and diagnoses, reliability of service and consistent evaluation of animal models and being a cost center for all animal costs. The fundamental expertise provided within the core is laboratory animal medicine and clinical and anatomic pathology. The Core is housed and coordinated in the Department of Veterinary Biosciences. Dr. Stefan Niewiesk, proposed Core Director has been co-director of the Animal Core since 2004 and is an active collaborator with all of the principal investigators for the PPG. He is certified in Veterinary Microbiology and as a Laboratory Animal Medicine Veterinarian (European). Because of Dr. Niewiesk's unique training, he also provides expertise in the generation of monoclonal and polyclonal antibodies for specific projects for the PPG. Dr. Thomas Rosol (Project 4, Co-Pi), who is certified by the American College of Veterinary Pathologist will serve as co-director for the Core. These investigators are joined by experienced technical staff to form a highly experienced professional team to guide the Core and meet the goals of the PPG investigators. A common thread among all research groups is the shared use of unique infectious molecular clones of HTLV-1 and HTLV-2, developed or characterized in our laboratories and links to established animal models to test molecular determinants of disease. Since 2003, the investigators have further evolved multiple new interdependent methods, techniques, and synergistic exchanges that serve to integrate their science to approach basic biological paradigms as desired outcomes from the project laboratories. The highly interactive Animal Core directed by Dr. Niewiesk will provide a central purchasing and procurement method to facilitate animal studies and to reduce redundancy and promote collaborations among the projects. A unique role of the Animal Core will be to provide faculty with expertise in mouse pathology, and provide state-of-the-art methods to determine and quantify bone lesions.