Control of intestinal inflammation by the D6 decoy chemokine receptor

趋化因子是一类在炎症反应中起重要作用的小分子化学信使，与过度或不适当的炎症反应引起的疾病有关。身体必须控制这些重要信使的水平和功能。其中一种方法是使用专门的分子结合趋化因子并破坏它们。我们已经发现了其中一种分子，称为D6，可以清除炎症趋化因子。然而，令人惊讶的是，我们最近的研究表明，D6实际上可能在肠道炎症中发挥积极作用，而不是预防它。这与免疫系统的另一种重要化学信使白细胞介素17的产生增加有关。本申请的目的是通过发现D6存在于结肠中的哪些细胞上以及通过检查D6如何控制肠中的白细胞介素17来研究D6如何控制结肠炎。我们将研究被称为树突状细胞（DC）的专门细胞，它们可以刺激其他细胞优先产生白细胞介素17。通过了解肠道中这些不同化学信使之间的联系，我们希望最终有助于开发炎症性疾病的新疗法

Chemokines are small chemical messengers which play an important role in inflammation and are involved in the diseases caused by excessive or inappropriate inflammation. The body has to control the levels and functions of these important messengers. One way this can be done is by the use of specialised molecules that bind chemokines and destroy them. We have discovered one of these molecules, known as D6, that removes inflammatory chemokines. However, surprisingly, our recent work suggests that D6 may actually have a positive role in intestinal inflammation rather than preventing it. This is associated with increased production of another important chemical messenger of the immune system, interleukin 17. The purpose of this application is to investigate how D6 can control colitis, by finding which cells it is present on in the colon and by examining how D6 controls interleukin 17 in the intestine. We will look at specialised cells known as dendritic cells (DC) which are known to stimulate other cells to make interleukin 17 preferentially. By understanding the links between these different chemical messengers in the intestine, we hope ultimately to assist the development of new treatments for inflammatory diseases