GERMPLASM & PHYTOCHEMICAL PROFILING/NIKOLAU, BASIL

爱荷华州植物补充剂研究中心的核心A有五个长期目标，以支持 中心内正在进行的研究，以提高我们对人类健康益处的理解， 膳食补充剂、紫锥菊、金丝桃和夏枯草的潜在风险。 一是扩大紫锥菊和金丝桃属植物种质资源综合收集， 收集夏枯草，以一种旨在代表广泛的分类，遗传和 生化多样性，并通过控制授粉种子生产和营养繁殖植物 手段通过这种方式，这些有据可查的和有特点的植物收藏品将可用于 研究中心的研究人员和更广泛的研究社区。 第二，我们将积极在中北部地区管理这些药用植物种质资源。 植物引种站（NCRPIS）作为美国国家植物种质系统的一部分，沿着所有数据 与它们的起源，分类身份和生化特征有关，这将使 可通过因特网在种质资源信息网络（GRIN）数据库中获得。 第三，我们将在控制下生产这些植物的已知来源种群的营养材料， 在NCRPIS的条件，通过现场和受控环境文化，以及服务- 为该中心的研究项目提供具有特色的植物材料。 第四，我们将对这些植物中发现的植物化学物质进行指纹分析和化学鉴定， 植物进行分析研究，在爱荷华州州立大学的W. M。凯克代谢组学研究 实验室 最后，我们将调查环境和发育线索对植物化学物质的影响， 紫锥菊、金丝桃、夏枯草种质资源的指纹图谱，以夏枯草为主， 了解环境和植物发育对其化学特征的作用。 这些核心活动提供了有价值的工具，使研究人员，谁研究的生物活性和毒性 这些植物补充剂的组分，用于挑选植物物种之间的变异的方法， 人口被用作这些补充剂的来源。这是研究中的一个复杂因素 所有的植物补充剂。通过使用已知来源的材料，这些材料具有良好的生物化学特性， 中心的研究人员可以更有效地识别生物活性成分，并提出建议， 更好的临床试验，以最大限度地提高这些补充剂对人类健康的益处，同时最大限度地降低风险 向消费者

Core A of the Iowa Center for Botanical Supplement Research has five long-term objectives in support of the research being conducted within the Center to improve our understanding of the human health benefits and potential risks of the dietary supplements, Echinacea, Hypericum, and Prunella. First, we will expand comprehensive plant germplasm collections of Echinacea and Hypericum, and develop collections of Prunella, in a manner designed to represent a broad range of taxonomic,genetic and biochemical diversity, and to propagate the plants through control-pollinated seed production and vegetative means. In this way, these well-documented and characterized plant collections will be made available for research by Center investigators and the broader research community. Second, we will actively curate these medicinal plant germplasm collections at the North Central Regional Plant Introduction Station (NCRPIS) as part of the US National Plant Germplasm System, along with all data associated with their origins, taxonomic identities, and biochemical characteristics, which will be made available via the Internet in the Germplasm Resources Information Network (GRIN) database. Third, we will produce vegetative materials of known-source populations of these plants under controlled conditions at the NCRPIS, through both field and controlled-environment culture, to serve as well- characterized plant materials for the Center's research projects. Fourth, we will conduct fingerprint analyses and chemical identification of the phytochemicals found in these plants by conducting analytical research at Iowa State University's W.M. Keck Metabolomics Research Laboratory. And finally, we will survey the effects of environmental and developmental cues on the phytochemical fingerprints of germplasm collections of Echinacea, Hypericum, Prunella, focusing on Prunella, where little is known about the roles of environment and plant development on its chemical profiles. These core activities provide valuable tools that allow researchers, who study the bioactive and toxic components of these botanical supplements, methods for sorting out variation among plant species and populations being used as sources for these supplements. This has been a complicating factor in the study of all botanical supplements. By using known-source materials that are well characterized biochemically, Center researchers can more efficiently identify bioactive components, and make recommendations that lead to better clinical trials to maximize the human health benefits from these supplements while minimizing risks to consumers.