Mentored Scholars Program for Translational Comparative Effectiveness Research

描述（由申请人提供）：本申请概述了一个新的KM1培训计划，该计划在一个新兴领域被称为转化比较有效性研究（T-CER）。具体目标是发展翻译比较有效性研究这一学科，具体目标如下：1)开发新的课程，以加强犹他州临床和转化科学中心临床研究硕士（MSCI）项目的T-CER课程；2)培养多样化的研究人员骨干，他们能够领导跨学科团队开展和传播与利益相关者相关的T-CER，与国家优先事项保持一致，并能够改善医疗保健服务和健康结果；3)跟踪和衡量学者的研究生产力。实施和传播，以及他们的研究对社区、卫生保健系统和当地和/或全国卫生结果的影响。转化科学原理丰富了比较有效性研究的过程和结果。犹他州强大的研究环境为CER的新兴领域和培训年轻研究人员提供了理想的环境。犹他州临床和转化科学中心（CCTS）为该项目提供了强大的基础设施，包括已建立的临床研究理学硕士学位和比较有效性研究证书。CCTS合作机构提供一系列临床研究人员和科学家作为KM1学者的导师。这些导师在CER方法、临床和转化研究、社区参与、经济学、统计学和职业发展方面的专业知识在国内和国际上享有盛名。犹他州研究机构和社区的合作性质也确保了我们有一个多样化的教师群体，他们可以作为学者参与其中。拟议的计划与2009年ARRA的目标完全一致。我们将让科学为医疗改革的利益服务，并利用联邦协调委员会的CER战略框架来实现NIH的目标。该项目是对CER人力和科学资本的战略投资，将通过纳入包括社区参与在内的临床和转化研究原则来推进该领域的发展。我们期望我们的毕业生通过进行创新研究，提供可以在现实环境中使用的数据，以提高医疗决策，从而成为国家的领导者。拟议的KM1项目是位于犹他州CCTS的T-CER的指导项目，将与犹他大学健康科学中心现有的职业发展项目很好地结合在一起。CCTS MSCI学位课程提供临床研究方面的课堂和指导研究经验，为学员在学术医学和相关健康科学领域从事临床研究做好准备。该项目将学员培养为有竞争力的研究者，能够为他们的临床研究项目获得校外资助。MSCI的课程侧重于理论、模型、方法和研究人员使用的工具，这些研究人员进行从床到床和从床到社区的转化研究。犹他大学的MSCI项目侧重于跨学科的团队科学，并为受训者创造了与跨研究周期的科学家互动的机会。KM1培训计划的申请也将把团队科学的原则纳入T-CER学者的培训课程。MSCI学位的博士后专业候选人将接受强调流行病学、卫生服务研究和从病床到社区的转化研究的培训。T- CER中拟议的KM1项目将纳入MSCI学位授予计划的第二轨，第二轨课程将扩大，以增加与CER相关的课程。现有的指导教师和机构资源可以容纳和支持拟议的T-CER学者的增加。参与者将从犹他州所有CCTS合作伙伴和国家CTSA联盟中招募。我们建议在本申请的第一年和第二年招收至少3名两年制学者，共计6名学者。拟议的T-CER培训计划的直接目标是培养一支能够领导跨学科团队进行和传播T-CER的多样化研究骨干。我们相信这个项目将补充现有的项目，并允许将严格的CER方法和训练有素的CER研究者纳入目前正在各机构接受培训的T1-T3科学团队。长期目标是将这些T-CER学者发展成为CER研究的国家领导者，他们正在进行与利益相关者相关的研究，与国家优先事项保持一致，并能够改善医疗保健服务和健康结果。

DESCRIPTION (provided by applicant): This application outlines a novel KM1 training program in an emerging field referred to as Translational Comparative Effectiveness Research (T-CER). The Specific Aims are to develop the discipline of translational comparative effectiveness research as follows: 1) Develop new courses that will enhance the T-CER curriculum of the Utah Center for Clinical and Translational Science Masters of Clinical Investigation (MSCI) Program, 2) Train a diverse cadre of investigators capable of leading interdisciplinary teams in conducting and disseminating T-CER that is relevant to stake holders, aligned with national priorities, and able to improve healthcare delivery and health outcomes, and 3) Track and measure the scholars' research productivity, implementation, and dissemination, and the effect of their research on communities, health care systems, and health outcomes locally and/or nationally. Translational science principles enrich the process and outcomes of comparative effectiveness research. Utah's robust research environment provides the ideal setting for the emerging field of CER and for training young investigators. The Utah Center for Clinical and Translational Science (CCTS) offers a strong infrastructure for the program including an established Masters of Science in Clinical Investigation and a Certificate in Comparative Effectiveness Research. CCTS partner institutions offer an array of clinician investigators and scientists to serve as mentors for the KM1 scholars. These mentors are known nationally and internationally for their expertise in CER methods, clinical and translational research, community engagement, economics, statistics, and career development. The collaborative nature of the Utah research institutions and community also ensures that we have a diverse pool of faculty who can participate as scholars. The proposed program is well aligned with the goals of the ARRA of 2009. We will put science to work for the benefit of health care reform and use the strategic framework of the Federal Coordinating Council for CER to reach NIH goals. The program is a strategic investment in human and scientific capital for CER and will advance the field by incorporating principles of clinical and translational research including community engagement. We expect our graduates to become national leaders by performing innovative research that will provide data that can be used in real-world settings to enhance medical decision-making. The proposed KM1 program is a Mentored Program in T-CER housed in the Utah CCTS and will be well integrated with the existing career development programs at the University of Utah Health Sciences Center. The CCTS MSCI degree program provides classroom and mentored research experience in clinical research, preparing its trainees for careers in clinical investigation, both in academic medicine and the allied health sciences. The program prepares trainees to be competitive investigators capable of gaining extramural funding for their clinical research projects. The curriculum of the MSCI focuses on the theories, models, methods, and tools used by investigators who conduct bench-to-bedside and bedside-to-community translational research. The University of Utah MSCI programs focus on interdisciplinary team science and create opportunities for trainees to interact with scientists working across the research cycle. This application for a KM1 training program will also incorporate the principles of team science into the training curriculum for the T-CER scholars. Post-doctoral professional candidates for the MSCI degree will receive training that emphasizes epidemiology, health services research, and bedside-to-community translational research. The proposed KM1 program in T- CER will be incorporated into Track 2 of the MSCI degree-granting program and the Track 2 curriculum will be expanded to increase course work related to CER. The existing mentoring faculty and institutional resources can accommodate and support the addition of the proposed T-CER scholars. Participants will be recruited from all Utah CCTS partners and the national CTSA consortium. We propose recruiting at least 3 two-year scholars in years one and two of this application for a total of 6 scholars. The immediate goal of the proposed T-CER training program is to train a diverse cadre of investigators capable of leading interdisciplinary teams in conducting and disseminating T-CER. We believe this program will complement the existing programs and allow the incorporation of rigorous CER methodology and well- trained CER investigators into the T1-T3 scientific teams currently being trained across the institutions. The long-term goal is to develop these T-CER scholars into national leaders in CER research who are conducting research that is relevant to stakeholders, aligned with national priorities, and able to improve healthcare delivery and health outcomes. PUBLIC HEALTH RELEVANCE: We will train investigators able to perform Translational Comparative Effectiveness Research. This training and program will increase the U.S. capacity to perform research designed to put science to work for the benefit of health care reform and to improve the health outcomes of all Americans.