Clinical Ascertainment and Phenotype

核心B：临床确定和表型核心将建立临床和表型 对该计划至关重要的分类。核心B还将管理所有的生物资源 程序。核心B的目标是招募家族性间质性肺炎的患者和家庭成员 (FIP)，以表征所有表型，并获得进行所有研究所需的标本 程序。核心B人员和设施将履行以下关键职能：1)确定患者和家属，2)招募，3)表型鉴定，4)数据库维护，5)标本获取和储存，6)标本检索和分配，7)端粒长度分析。所有3个站点(范德比尔特、科罗拉多国立犹太大学和杜克大学)的核心B研究协调员在Progeny Software(新斯科舍省沃尔夫维尔)中输入和维护一个详细的数据库，包括每个家庭的血统信息和每个人的表型。核心B实验室人员将负责标本处理、细胞培养、存储和管理标本数据。CORE B将为项目研究人员提供生物材料(血清、淋巴细胞、淋巴母细胞、肺组织)和高通量分子生物学服务(端粒长度分析)。

CORE B: The Clinical Ascertainment and Phenotyping Core will establish the clinical and phenotypic classifications which are pivotal for the Program. Core B will also manage all of the biologic resources for the Program. The goal of Core B is to recruit patients and members of families with familial interstitial pneumonia (FIP), to characterize all phenotypes, and obtain the specimens needed to conduct all studies ofthe Program. Core B personnel and facilities will perform the following key functions: 1) patient and family ascertainment, 2) recruitment, 3) phenotyping, 4) database maintenance, 5) specimen acquisition and banking, 6) specimen retrieval and distribution, 7) telomere length analyses. Core B study coordinators at all 3 sites (Vanderbilt, National Jewish/Univ Colorado, and Duke) enter and maintain a detailed database in Progeny Software (Wolfville, Nova Scotia), including pedigree information on each family and phenotype on each individual. Core B laboratory personnel will be responsible for specimen processing, cell culture, storage and management of specimen data. Core B will provide biomaterials (serum, lymphocytes, lymphoblastoids, lung tissue) and high throughput molecular biology services (telomere length analyses) to Program investigators.