Self-report versus medical record data in a study of infant leukemia

描述(由申请人提供)： 摘要病例对照研究是开展儿童癌症流行病学研究的标准。然而，目前还不清楚这些研究在评估母亲回忆方面存在多大的偏见。怀孕期间的医疗记录提供了一个优势，因为它们是在癌症诊断之前收集的，从而消除了许多回忆偏见。然而，收集病历可能既困难又昂贵。我们试图通过将这些数据与她的医疗记录进行比较来确定母亲自我报告的怀孕前后事件的有效性。将使用婴儿白血病病例对照研究中自我报告的数据。采访要求母亲回忆怀孕期间和怀孕后的事件，包括医疗条件、月经、激素使用、避孕史、分娩和分娩，以及婴儿出生特征和住院时间。我们的目标是以医疗记录为“黄金标准”，计算在两个数据集中具有可比性的项目的敏感度和特异度。我们的目的是使用这些数据来调整母亲访谈的优势比估计，以防止使用概率不确定性分析进行错误分类。这项分析的结果将为我们在未来的病例对照研究中收集病历的必要性提供有价值的信息。这些分析将表明，母亲能够更准确地回忆起哪些健康状况。例如，如果母亲能够回忆起怀孕期间的事件，那么未来的病例对照研究可能就不需要医疗记录了。此外，我们的研究结果将为研究人员和其他感兴趣的各方提供非随机错误率的特定值，以便更全面地评估婴儿白血病研究的相关性。最后，目前的应用以及我们发表的其他研究将提供与非随机误差相关的不确定性的广泛知识。这些已发表的结果将有助于向流行病学家说明如何在他们自己的研究中实施非随机误差的定量分析，从而改善对流行病学研究结果的解释。 公共卫生相关性： 投射叙事(公共卫生句)：这是流行病学中一个重要且调查不足的领域，可能适用于为未来的病例对照研究改进数据收集。

DESCRIPTION (provided by applicant): ABSTRACT The case-control approach is the standard in conducting epidemiological studies of childhood cancer. It is unclear, however, how much bias exists in evaluating maternal recall in these studies. Medical records around the time of pregnancy provide an advantage in that they are collected prior to the diagnosis of cancer, thereby eliminating much recall bias. However, medical records can be difficult and expensive to collect. We seek to determine the validity of a mother's self-reported events around pregnancy by comparing that data to her medical record. Self-reported data from a case-control study of infant leukemia will be used. The interview asked mothers to recall events during and after her pregnancies, including medical conditions, menstrual, hormone-use, and contraceptive history, labor and delivery, and infant birth characteristics and hospitalization. Our goal is to calculate sensitivity and specificity values for items that are comparable in the two datasets, using the medical record as the "gold standard." Our purpose is to use these data to adjust the odds ratios estimates from the maternal interview for misclassification using probabilistic uncertainty analyses. Results of this analysis will provide us with valuable information regarding the need to collect medical records in future case-control studies. The analyses will indicate which health conditions mothers are able to recollect more accurately. If the mothers are able to recall events during pregnancy, for instance, then medical records may not be needed for future case-control studies. Further, the findings from our research will provide investigators and other interested parties with specific values for nonrandom error rates for more comprehensive evaluations of associations from the infant leukemia study. Lastly, the current application along with our other published research will provide a broad range of knowledge of the uncertainty associated with nonrandom errors. These published results will help illustrate to epidemiologists how to implement quantitative analysis of nonrandom error into their own research and thereby improve the interpretation of epidemiologic study results. PUBLIC HEALTH RELEVANCE: Projective Narrative (Public Health Sentence): This is an important and under-investigated area of epidemiology that has potential applicability to improving the collection of data for future case-control studies.