Self-report versus medical record data in a study of infant leukemia

婴儿白血病研究中的自我报告与病历数据

• 批准号: 7736391
• 负责人: Anne M. Jurek
• 金额: $ 8.52万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7736391
• 关键词: 20 year old; Adolescent; Area; Birth; Case-Control Studies; Characteristics; Child; Childhood; Children' s Oncology Group; Consent; Contraceptive History; Data; Data Collection; Data Set; Disadvantaged; Disease; Epidemiologic Studies; Epidemiologist; Epidemiology; Evaluation; Event; Funding; Future; Goals; Gold; Health; Hormones; Hospitalization; Hospitals; Incidence; Individual; Infant; Interview; Knowledge; Life; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Measures; Medical; Medical Records; Mothers; Newly Diagnosed; Odds Ratio; Patient Self-Report; Pregnancy; Public Health; Publishing; Rare Diseases; Research; Research Design; Research Personnel; Risk Factors; Sensitivity and Specificity; Source; Techniques; Telephone Interviews; Time; Uncertainty; United States; abstracting; analytical tool; base; cancer diagnosis; case control; design; improved; indexing; interest; leukemia; public health relevance; tool

DESCRIPTION (provided by applicant): ABSTRACT The case-control approach is the standard in conducting epidemiological studies of childhood cancer. It is unclear, however, how much bias exists in evaluating maternal recall in these studies. Medical records around the time of pregnancy provide an advantage in that they are collected prior to the diagnosis of cancer, thereby eliminating much recall bias. However, medical records can be difficult and expensive to collect. We seek to determine the validity of a mother's self-reported events around pregnancy by comparing that data to her medical record. Self-reported data from a case-control study of infant leukemia will be used. The interview asked mothers to recall events during and after her pregnancies, including medical conditions, menstrual, hormone-use, and contraceptive history, labor and delivery, and infant birth characteristics and hospitalization. Our goal is to calculate sensitivity and specificity values for items that are comparable in the two datasets, using the medical record as the "gold standard." Our purpose is to use these data to adjust the odds ratios estimates from the maternal interview for misclassification using probabilistic uncertainty analyses. Results of this analysis will provide us with valuable information regarding the need to collect medical records in future case-control studies. The analyses will indicate which health conditions mothers are able to recollect more accurately. If the mothers are able to recall events during pregnancy, for instance, then medical records may not be needed for future case-control studies. Further, the findings from our research will provide investigators and other interested parties with specific values for nonrandom error rates for more comprehensive evaluations of associations from the infant leukemia study. Lastly, the current application along with our other published research will provide a broad range of knowledge of the uncertainty associated with nonrandom errors. These published results will help illustrate to epidemiologists how to implement quantitative analysis of nonrandom error into their own research and thereby improve the interpretation of epidemiologic study results. PUBLIC HEALTH RELEVANCE: Projective Narrative (Public Health Sentence): This is an important and under-investigated area of epidemiology that has potential applicability to improving the collection of data for future case-control studies.

描述（由申请人提供）： 病例对照研究方法是进行儿童癌症流行病学研究的标准。然而，目前还不清楚这些研究中评估母亲回忆存在多少偏见。怀孕前后的医疗记录提供了一个优势，因为它们是在癌症诊断之前收集的，从而消除了许多回忆偏差。然而，医疗记录的收集是困难和昂贵的。我们试图通过比较数据和她的医疗记录来确定母亲在怀孕期间自我报告的事件的有效性。将使用来自婴儿白血病病例对照研究的自我报告数据。采访要求母亲回忆怀孕期间和怀孕后的事件，包括医疗条件，月经，避孕药使用和避孕史，分娩和分娩，婴儿出生特征和住院治疗。我们的目标是计算敏感性和特异性值的项目，在两个数据集是可比的，使用医疗记录作为“金标准”。“我们的目的是使用这些数据来调整使用概率不确定性分析进行错误分类的母亲访谈的优势比估计。本分析的结果将为我们提供有价值的信息，需要收集的病历在未来的病例对照研究。这些分析将表明母亲能够更准确地选择哪些健康状况。例如，如果母亲能够回忆起怀孕期间的事件，那么未来的病例对照研究可能就不需要医疗记录。此外，我们的研究结果将为研究者和其他相关方提供非随机错误率的具体值，以便更全面地评估婴儿白血病研究的相关性。最后，当前的应用沿着我们的其他已发表的研究将提供与非随机误差相关的不确定性的广泛知识。这些发表的结果将有助于向流行病学家说明如何在自己的研究中实施非随机误差的定量分析，从而改善对流行病学研究结果的解释。 公共卫生关系： 投射性叙述（公共卫生句子）：这是流行病学的一个重要和未充分调查的领域，对改善未来病例对照研究的数据收集具有潜在的适用性。