Characterisation of norovirus replication complex formation

杯状病毒家族的成员对人和动物的重要疾病负有责任；诺如病毒在人类中引起胃肠炎或抛射性呕吐，疫情经常在医院、游轮和军营中出现。关于这些病毒如何与宿主细胞相互作用以及如何导致新病毒颗粒的产生，我们目前知之甚少。当诺如病毒感染宿主细胞时，它们有许多影响，可以改变宿主细胞内发生的正常过程。一个这样的影响是产生复制？工厂？在复制病毒基因组的宿主细胞内。为了更好地了解这一重要的病毒家族，我们现在的目标是描述这些复制工厂？以确定控制这些重要病毒爆发的方法。

Members of the calicivirus family are responsible for important diseases of man and animals; noroviruses cause gastroenteritis or projectile vomiting in humans and outbreaks are often seen in hospitals, cruise ships and in military camps. We currently know very little with regards to how these viruses interact with the host cell and how this leads to the production of new virus particles. When noroviruses infect a host cell they have many effects that can alter the normal processes occurring within the host cell. One such effect is to generate replication ?factories? within the host cell where the viral genome is replicated. In order to better understand this important family of viruses, we now aim to characterise how these replication ?factories? are generated to identify methods of controlling outbreaks of these important viruses.