The role of endosomal sorting proteins in HSV-1 assembly

疱疹病毒是一组重要的病原体，可以感染人类并引起多种医学问题，包括唇疱疹、带状疱疹和腺热。疱疹病毒还会增加患某些类型癌症的风险，并可能对免疫抑制的人（如移植患者）造成危及生命的疾病。为了能够治疗和控制这些病毒的感染，至关重要的是我们要了解这些病毒是如何感染我们的，它们是如何产生新的自我复制的，以及它们是如何传播给新的人群的。这项被提议的研究将使用细胞培养模型来研究疱疹病毒如何控制我们细胞自身的机制，从而形成新的病毒拷贝。总的来说，从这项研究中获得的信息将使我们更好地了解这种重要的病毒家族是如何在我们的细胞中感染和复制的。这些信息有望确定新的靶标，这些靶标可以被药物抑制，以对抗这些病毒和由它们引起的许多疾病。

The herpesviruses are an important group of pathogens that infect humans and cause several medical problems including cold sores, shingles and glandular fever. Herpesviruses can also increase the risk of certain types of cancer, and can cause life-threatening conditions in immune-suppressed people, such as transplant patients. To be able to treat and control infections by these viruses, it is crucial that we understanding how these viruses infect us, how they produce new copies of themselves, and how they spread to new people. The research being proposed will use cell culture models to study the way in which herpesviruses control our cells own machinery in order to form new copies of the virus. Overall, the information gained from this research will give a greater understanding of how this important family of viruses can infect and replicate in our cells. Such information will hopefully identify new targets that could be inhibited by drugs to combat these viruses and the many diseases caused by them.