Engineering for Neurologic Rehabilitation

描述(由申请人提供)：这项名为“神经康复工程”的R24研究资源旨在传播PIS在工程和神经科学方面的核心专业知识，以支持全美医疗中心和医院的新教师发展。该计划将建立在PIS当前R24网络的支持下建立的核心设施，并在NIDRR赞助的类似研究中心下支持中风和其他神经疾病的机器人研究。这些核心设施包括：1.神经科学核心：董事是C.J.赫克曼(西北大学)和乔治·霍恩比(UIC)。赫克曼博士领导的实验室使用电生理学、解剖学、免疫组织化学和药理学方法处理脊髓损伤的动物模型。该实验室将可用于进行人体试验的准备研究。霍恩比博士的核心将促进在人类群体中进行临床测试。2.机器人学/机械学核心：导演是詹姆斯·巴顿和桑德罗·穆萨-利瓦尔迪。他们将提供一系列不同的机器人和机械系统，专为基础研究、诊断研究以及测试中风和脊髓损伤的治疗方法而设计。新的机器人系统，如触觉大师和其他特殊用途的机器人，也将用于协作互动。此外，还将提供使用“Lokomat”作为诊断和治疗工具的步态研究。3.信息技术/传感核心：导演是张立群和保罗·博纳托(Spaulding)。这一核心设施有能力建造新的电子系统，如最先进的肌电电极、遥测数据采集系统以及广泛的建模和仿真设施。4.建模与仿真核心：温迪·默里和牙生·达赫。这些研究核心的提供情况将通过专门的网站传播，并在国家和国际会议上介绍。最后，将提供一系列教学课程、实践工作坊和座谈会，以展示新颖的研究方法。 公共卫生相关性：这个R24研究资源应用程序寻求建立在神经科学和工程学专业知识的基础上，这些专业知识集中在芝加哥康复研究所的研究实验室和西北大学的附属实验室。PI提供了在动物模型和人类群体中与神经疾病相关的研究方面的合作机会。

DESCRIPTION (provided by applicant): This R24 research resource, called "Engineering for Neurological Rehabilitation" seeks to disseminate the PIs' core expertise in engineering and neuroscience to support the development of new faculty in medical centers and hospitals across the United States. This program will build on core facilities established under the auspices of the PIs' current R24 network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following: 1. Neurosciences Core: Directors are C.J. Heckman (Northwestern) and George Hornby (UIC). Dr. Heckman directs a laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Dr. Hornby's core will facilitate clinical testing in human populations. 2. Robotics/Mechanics Core: Directors are James Patton and Sandro Mussa-lvaldi. They will make available an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. New robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be offered. 3. Information Technology/Sensing Core: Directors are Li-Qun Zhang and Paolo Bonato (Spaulding). This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered data collection systems, and extensive modeling and simulation facilities. 4. Modeling and Simulation Core: Wendy Murray and Yasin Daher. Availability of these research cores will be disseminated through dedicated websites and presented at national and international meetings. Finally, a series of didactic courses, hands-on workshops, and symposia will be offered to present novel research approaches. PUBLIC HEALTH RELEVANCE: This R24 research resource application seeks to build on expertise in neuroscience and engineering that is concentrated in the research laboratories of the Rehabilitation Institute of Chicago, and in affiliated laboratories at Northwestern University. The PIs offer opportunities for collaboration on studies relating to neurological disorders in animal models, and in human populations.