ENGINEERING FOR NEUROLOGIC REHABILITATION

描述（由申请人提供）：这个基础设施研究核心称为“神经康复工程”，旨在扩大和传播PI在工程和神经科学方面的核心专业知识，以帮助支持美国各地医疗中心和医院的新教师的发展。该计划将建立在目前区域研究（R24）网络和类似的NIDRR赞助的研究中心支持中风和其他神经系统疾病的机器人研究的主持下，在PI中心建立的核心设施。这些核心设施包括：（1）由James Patton，Yasin Dhaher和Sandro Mussa-lvaldi指导的机器人/机械核心。PI计划为合作研究提供一系列不同的机器人和机械系统，用于基础研究，诊断研究以及测试中风和脊髓损伤的治疗方法。这些机器人包括上肢机器人系统，如MIT Manus，RIC平面机器，称为到达指南，Phantom和WAM，一种新型的可反向驱动的三维机器人系统。此外，新的机器人系统，如触觉大师和其他特殊用途的机器人也将提供协作互动，一旦他们被集成到PI的研究计划。此外，将向合作者提供使用“Lokomat”作为诊断和治疗工具的步态研究，以供试点研究。(2)一个信息技术的核心，由张立群和德里克坎珀导演。该核心设施有能力构建新型电子系统，如最先进的EMG电极、遥测采集系统、先进的信号处理系统以及广泛的建模和仿真设施。(3)神经科学核心，由C. J.赫克曼和乔治霍恩比执导。Heckman博士指导一个研究实验室，使用电生理学，解剖学，免疫组织化学，化学和药理学方法处理脊髓损伤的动物模型。该实验室将可用于进行人体试验的准备研究。其他可用的方法包括使用H反射的电生理测试，以及用于研究脊髓回路和兴奋性的经颅磁刺激。这些核心研究项目以及其他核心发展项目的提供情况将通过专门网站传播，并在国家和国际会议上介绍。PI还计划提供短期或长期的休假机会，以合作研究使用这些不同的核心。最后，还将提供一系列教学课程，实践研讨会和研讨会，以展示这些工程领域的新颖研究主题。

DESCRIPTION (provided by applicant): This infrastructure research core called "Engineering for Neurological Rehabilitation" seeks to expand and disseminate the PIs core expertise in engineering and in neuroscience to help support the development of new faculty in medical centers, and hospitals across the United States. This program will build on core facilities established in the PIs center under the auspices of the current regional research (R24) network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following (1) A Robotics/Mechanics Core, directed by James Patton, Yasin Dhaher, and Sandro Mussa-lvaldi. The PIs plan to make available for collaborative research an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. These robots include upper extremity robotics systems such as the MIT Manus, an RIC planar machine called the reaching guide, the Phantom, and WAM, a novel backdriveable three-dimensional robotics system. In addition, new robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction, once they are integrated into the PIs' research programs. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be made available to collaborators for pilot studies. (2) An Information Technology Core, directed by Li-Qun Zhang and Derek Kamper. This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered collection systems, advancing signal processing systems, and extensive modeling and simulation facilities. (3) A Neurosciences Core, directed by C.J. Heckman and George Hornby. Dr. Heckman directs a research laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, chemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Other approaches available include the use of electrophysiological testing using H reflexes, and transcranial magnetic stimulation for study of spinal cord circuitry and excitability. Availability of these research cores, as well as other core development projects, will be disseminated through dedicated websites and presented at national and international meetings. The PIs also plan to offer short- or long-term sabbatical opportunities to collaborate in studies using these various cores. Finally, a series of didactic courses, hands-on workshops, and symposia will also be offered to present novel research themes in these engineering areas.