ENGINEERING FOR NEUROLOGIC REHABILITATION

描述(申请人提供)：这个名为“神经康复工程”的基础设施研究核心致力于扩展和传播PIS在工程学和神经科学方面的核心专业知识，以帮助支持全美医疗中心和医院的新教师发展。该计划将在PIS中心建立的核心设施的基础上，在当前区域研究(R24)网络的支持下，以及在NIDRR赞助的类似研究中心下，支持中风和其他神经疾病的机器人研究。这些核心设施包括(1)由詹姆斯·巴顿、牙生·达赫和桑德罗·穆萨-瓦尔迪指导的机器人/机械学核心。PIS计划为合作研究提供一系列不同的机器人和机械系统，这些系统旨在进行基础研究、诊断研究以及测试中风和脊髓损伤的治疗方法。这些机器人包括上肢机器人系统，如麻省理工学院的Manus，一种名为到达指南的RIC平面机器，幻影，以及WAM，一种新型的后驱动三维机器人系统。此外，新的机器人系统，如触觉大师和其他特殊用途的机器人，一旦被整合到私人投资机构的研究计划中，也将用于协作互动。此外，使用“Lokomat”作为诊断和治疗工具的步态研究将提供给合作者进行试点研究。(2)由张立群和德里克·坎珀执导的《信息技术核心》。这一核心设施有能力建造新的电子系统，如最先进的肌电电极、遥测采集系统、先进的信号处理系统以及广泛的建模和仿真设施。(3)由C.J.赫克曼和乔治·霍恩比执导的《神经科学核心》。赫克曼博士领导着一个研究实验室，使用电生理、解剖学、免疫组织化学、化学和药理学方法处理脊髓损伤的动物模型。该实验室将可用于进行人体试验的准备研究。其他可用的方法包括使用H反射的电生理测试，以及用于研究脊髓回路和兴奋性的经颅磁刺激。这些研究核心以及其他核心发展项目的提供情况将通过专门的网站传播，并在国家和国际会议上介绍。PIS还计划提供短期或长期的休假机会，利用这些不同的核心在研究中进行合作。最后，还将提供一系列教学课程、实践工作坊和座谈会，以展示这些工程领域的新颖研究主题。

DESCRIPTION (provided by applicant): This infrastructure research core called "Engineering for Neurological Rehabilitation" seeks to expand and disseminate the PIs core expertise in engineering and in neuroscience to help support the development of new faculty in medical centers, and hospitals across the United States. This program will build on core facilities established in the PIs center under the auspices of the current regional research (R24) network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following (1) A Robotics/Mechanics Core, directed by James Patton, Yasin Dhaher, and Sandro Mussa-lvaldi. The PIs plan to make available for collaborative research an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. These robots include upper extremity robotics systems such as the MIT Manus, an RIC planar machine called the reaching guide, the Phantom, and WAM, a novel backdriveable three-dimensional robotics system. In addition, new robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction, once they are integrated into the PIs' research programs. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be made available to collaborators for pilot studies. (2) An Information Technology Core, directed by Li-Qun Zhang and Derek Kamper. This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered collection systems, advancing signal processing systems, and extensive modeling and simulation facilities. (3) A Neurosciences Core, directed by C.J. Heckman and George Hornby. Dr. Heckman directs a research laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, chemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Other approaches available include the use of electrophysiological testing using H reflexes, and transcranial magnetic stimulation for study of spinal cord circuitry and excitability. Availability of these research cores, as well as other core development projects, will be disseminated through dedicated websites and presented at national and international meetings. The PIs also plan to offer short- or long-term sabbatical opportunities to collaborate in studies using these various cores. Finally, a series of didactic courses, hands-on workshops, and symposia will also be offered to present novel research themes in these engineering areas.