Application for Centre for Regenerative Medicine
Application for Centre for Regenerative Medicine
批准号:
G0700711/1
负责人:
Charles Ffrench-Constant
金额:
$212.64万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2008
资助国家:
英国
项目状态:
已结题
起止时间:
2008 至 --
中文摘要
一个革命性的新医疗中心,苏格兰再生医学中心,已经在爱丁堡大学开放。该中心旨在通过对干细胞的研究开发新的疾病治疗方法。干细胞?是具有自我繁殖能力或形成组成不同组织的特化细胞的主细胞。科学家和医生相信,了解干细胞的行为将导致新疗法的发展。新的治疗方法可能包括替换病人体内被疾病损坏的细胞。在其他情况下,可能有可能确定能够使患者?我们自己的细胞进行修复。干细胞还将用于测试新药。目前,新药的效果是通过动物试验或动物细胞试验来衡量的。有时,由于人和动物之间的差异,结果会产生误导。通过使用人类细胞进行试验,科学家将减少使用动物的数量,并减少误导性结果导致代价高昂的延误的频率。SCRM的科学家已经确定了一些需要首先研究的疾病。选择这些研究是因为爱丁堡的科学家在研究这些疾病方面处于领先地位,而干细胞可能真正有助于治疗这些疾病。一个目标是能够更有效地修复骨骼,特别是协助髋关节修复。其他研究将试图开发修复神经系统的治疗方法,如多发性硬化症或运动神经元疾病。目前,许多肝病患者在找到适合移植的器官之前就死亡了。干细胞可以提供另一种治疗方法。干细胞可以用来修复免疫系统,让病人恢复健康。美国抵抗感染的能力。长期而言,其他方案将处理与癌症、糖尿病、心脏病和眼睛损伤有关的问题。SCRM将为安全有效地应用新疗法所需的基础科学家和医生提供高水平的培训。最后,SCRM将努力确保其研究的商业化,并与生物技术和制药公司密切合作。新中心的这些活动将有助于将英国置于国际干细胞科学的前沿,为新疗法的发展提供重要的新机会,并在英国创造高薪工作。
英文摘要
A revolutionary new medical Centre, the Scottish Centre for Regenerative Medicine, has been opened at the University of Edinburgh. The Centre aims to develop new treatments for disease through research into stem cells.?Stem cells? are master cells that have the ability either to multiply themselves or form the specialised cells that make up different tissues. Scientists and doctors believe that understanding how stem cells behave will lead to development of new treatments. The new treatments may involve replacing cells in the patient that have been damaged by disease. In other cases it may be possible to identify drugs that are able to make the patient?s own cells carry out the repair. Stem cells will also be used in testing new drugs. At present the effect of new drugs is measured in tests with animals or with cells from animals. Sometimes the results are misleading because of differences between humans and animals. By using human cells for tests, scientists will reduce the number of animals that are used and the frequency with which misleading results cause expensive delays. Scientists at SCRM have identified a number of diseases which to work on first. These are chosen because Edinburgh scientists lead the field in studying these diseases and stem cells may genuinely help to treat them. One aim is to be able to repair bone more effectively, especially to assist in hip repair. Other research will try to develop treatments to repair the nervous system, in diseases such as Multiple Sclerosis or Motor Neuron Disease. At present many patients with liver disease die before a suitable organ becomes available for transplantation. Stem cells may provide an alternative means of treatment. Stem cells may be used to repair the immune system and give back the patient?s ability to fight infections. In the longer term other programmes will address issues concerned with cancer, diabetes, heart disease and damage to the eye.SCRM will provide high class training for the basic scientists and the doctors needed for the new treatments to be applied safely and effectively. Finally, SCRM will work hard to ensure commercialisation of its research and work closely with biotechnology and pharmaceutical companies. Together these activities in the new Centre will help to position the UK at the forefront of international stem cell science, provide important new opportunities for development of novel therapies and create well paid jobs in the UK.
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MRC IAA 2021 University of East Anglia
-
批准号:MR/X502972/1
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项目类别:Research Grant
-
资助金额:$75.33万
-
财政年份:2022
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负责人:Charles Ffrench-Constant
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依托单位:
Edinburgh – Confidence in Concept 2019
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批准号:MC_PC_19035
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项目类别:Intramural
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资助金额:$136.81万
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财政年份:2020
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负责人:Charles Ffrench-Constant
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依托单位:
Driving innovation for human health at Edinburgh
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批准号:MC_PC_18046
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项目类别:Intramural
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资助金额:$91.74万
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财政年份:2019
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负责人:Charles Ffrench-Constant
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依托单位:
Delivering Translational Opportunities From Edinburgh (DTOFE)
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批准号:MC_PC_17159
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项目类别:Intramural
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资助金额:$120.28万
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财政年份:2018
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负责人:Charles Ffrench-Constant
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依托单位:
BUILDING EDINBURGH’S DRUG DISCOVERY ECOSYSTEM
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批准号:MC_PC_17188
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项目类别:Intramural
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资助金额:$18.9万
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财政年份:2018
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负责人:Charles Ffrench-Constant
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依托单位:
Discover Edinburgh Health Informatics
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批准号:MC_PC_16071
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项目类别:Intramural
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资助金额:$15.93万
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财政年份:2017
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负责人:Charles Ffrench-Constant
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依托单位:
The role of N-cadherin in neural stem cells
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批准号:BB/L00402X/1
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项目类别:Research Grant
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资助金额:$15.65万
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财政年份:2013
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负责人:Charles Ffrench-Constant
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依托单位:
MRC Centre for Regenerative Medicine
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批准号:MR/K017047/1
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项目类别:Research Grant
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资助金额:$247.28万
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财政年份:2013
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负责人:Charles Ffrench-Constant
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依托单位:
Development of retinal transplantation as an animal model to test stem cell therapies for myelin diseases
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批准号:G0802545/1
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项目类别:Research Grant
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资助金额:$32.79万
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财政年份:2009
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负责人:Charles Ffrench-Constant
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依托单位:
A functional proteomic screen of myelination
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批准号:G0601744/2
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项目类别:Research Grant
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资助金额:$19.4万
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财政年份:2008
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负责人:Charles Ffrench-Constant
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依托单位:
The role of N-cadherin in neural stem cells
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批准号:BB/E021190/1
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项目类别:Research Grant
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资助金额:$39.16万
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财政年份:2007
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负责人:Charles Ffrench-Constant
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依托单位:
A functional proteomic screen of myelination
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批准号:G0601744/1
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项目类别:Research Grant
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资助金额:$37.59万
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财政年份:2006
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负责人:Charles Ffrench-Constant
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依托单位:
海外基金