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Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices

医疗技术创新和知识中心二期再生设备

基本信息

批准号：
EP/N00941X/1
负责人：
Ruth Wilcox
金额：
$ 449.62万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN00941X%2F1
关键词：
Medical Technologies Innovation Knowledge Centre

项目摘要

Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field. The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry. In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.

再生装置（支架、生物材料和干预措施）可以使用患者自身的细胞修复和再生组织，可以转化为成功的临床产品，并以比其他再生疗法（例如培养扩增细胞疗法或分子（药物）疗法）低得多的成本和风险以及更短的时间为患者带来好处。据估计，到2020年，全球再生设备市场将增长到500亿英镑，这为英国在该领域每年增长10亿英镑的行业提供了真实的机会。英国在生物材料和组织工程，肌肉骨骼力学（EPSRC优先）和再生医学领域具有真正的研究优势。再生医学是研究委员会优先考虑的八大技术之一。研究发现、新知识、产出和成果往往还没有准备好被行业吸收，以便通过产品开发推向市场并使患者受益。新技术需要改进和降低风险。临床需求、潜在产品和市场需要加以界定，以使其对投资、产品开发和行业临床试验具有吸引力。在医疗技术创新和知识中心（MTIKC）第一阶段，我们与行业和临床合作伙伴合作，建立了专业的创新团队和独特的创新和翻译流程，创建了多学科的研究和创新生态系统。我们已经成功地确定了研究成果和新知识，并在创新死亡谷创造，先进和翻译技术，使工业和私营部门在新产品开发方面的成功投资（超过1亿英镑）。一些产品已经进入临床试验和商业化阶段，并正在实现患者利益。我们已经建立了一个持续创新的管道超过50个概念技术项目的证明，在未来五年的MTIKC第二阶段，我们将解决未满足的临床需求和市场机会，在伤口修复，心血管修复，肌肉骨骼组织修复，颌面重建，牙科重建和普通外科，并多元化我们的研究供应链到其他十多所大学。我们将支持150个与行业合作的项目，并启动40个新的行业启发和学术主导的概念验证项目，预计这些项目将导致私营部门在后续产品开发中进一步投资1亿英镑。这将使英国能够建立一个可持续的研究和产品开发管道，这将在2020年之后支持每年10亿英镑的再生设备行业。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Manufacturing Porous Microspheres from Bioactive Glasses for Orthobiologics Applications.

用生物活性玻璃制造多孔微球用于骨科生物应用。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Ahmed, I
通讯作者：
Ahmed, I

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.

DOI：
10.1177/0954411915620454
发表时间：
2016-05
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Ali M;Al-Hajjar M;Partridge S;Williams S;Fisher J;Jennings LM
通讯作者：
Jennings LM

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.

DOI：
10.1177/0954411917696519
发表时间：
2017-07
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Abdelgaied A;Fisher J;Jennings LM
通讯作者：
Jennings LM

Wear of composite ceramics in mixed-material combinations in total hip replacement under adverse edge loading conditions.