Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices
医疗技术创新和知识中心二期再生设备
基本信息
- 批准号:EP/N00941X/1
- 负责人:
- 金额:$ 449.62万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field. The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry. In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.
再生装置(支架、生物材料和干预措施)可以使用患者自身的细胞修复和再生组织,可以转化为成功的临床产品,并以比其他再生疗法(例如培养扩增细胞疗法或分子(药物)疗法)低得多的成本和风险以及更短的时间为患者带来好处。据估计,到2020年,全球再生设备市场将增长到500亿英镑,这为英国在该领域每年增长10亿英镑的行业提供了真实的机会。英国在生物材料和组织工程,肌肉骨骼力学(EPSRC优先)和再生医学领域具有真正的研究优势。再生医学是研究委员会优先考虑的八大技术之一。研究发现、新知识、产出和成果往往还没有准备好被行业吸收,以便通过产品开发推向市场并使患者受益。新技术需要改进和降低风险。临床需求、潜在产品和市场需要加以界定,以使其对投资、产品开发和行业临床试验具有吸引力。在医疗技术创新和知识中心(MTIKC)第一阶段,我们与行业和临床合作伙伴合作,建立了专业的创新团队和独特的创新和翻译流程,创建了多学科的研究和创新生态系统。我们已经成功地确定了研究成果和新知识,并在创新死亡谷创造,先进和翻译技术,使工业和私营部门在新产品开发方面的成功投资(超过1亿英镑)。一些产品已经进入临床试验和商业化阶段,并正在实现患者利益。我们已经建立了一个持续创新的管道超过50个概念技术项目的证明,在未来五年的MTIKC第二阶段,我们将解决未满足的临床需求和市场机会,在伤口修复,心血管修复,肌肉骨骼组织修复,颌面重建,牙科重建和普通外科,并多元化我们的研究供应链到其他十多所大学。我们将支持150个与行业合作的项目,并启动40个新的行业启发和学术主导的概念验证项目,预计这些项目将导致私营部门在后续产品开发中进一步投资1亿英镑。这将使英国能够建立一个可持续的研究和产品开发管道,这将在2020年之后支持每年10亿英镑的再生设备行业。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Manufacturing Porous Microspheres from Bioactive Glasses for Orthobiologics Applications.
用生物活性玻璃制造多孔微球用于骨科生物应用。
- DOI:
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Ahmed, I
- 通讯作者:Ahmed, I
Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.
- DOI:10.1177/0954411915620454
- 发表时间:2016-05
- 期刊:
- 影响因子:0
- 作者:Ali M;Al-Hajjar M;Partridge S;Williams S;Fisher J;Jennings LM
- 通讯作者:Jennings LM
The Influence of Kinematic Conditions and Variations in Component Positioning on the Severity of Edge Loading and Wear of Ceramic-on-Ceramic Hip Bearings
运动条件和部件定位变化对陶瓷陶瓷髋关节轴承边缘载荷和磨损严重程度的影响
- DOI:10.3390/ceramics2030037
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Ali M
- 通讯作者:Ali M
Wear of composite ceramics in mixed-material combinations in total hip replacement under adverse edge loading conditions.
- DOI:10.1002/jbm.b.33671
- 发表时间:2017-08
- 期刊:
- 影响因子:0
- 作者:Al-Hajjar M;Carbone S;Jennings LM;Begand S;Oberbach T;Delfosse D;Fisher J
- 通讯作者:Fisher J
A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.
全面的实验和计算框架,用于临时磨损的总膝盖置换。
- DOI:10.1016/j.jmbbm.2017.11.022
- 发表时间:2018-03
- 期刊:
- 影响因子:3.9
- 作者:Abdelgaied A;Fisher J;Jennings LM
- 通讯作者:Jennings LM
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Ruth Wilcox其他文献
FE MODELS OF HUMAN VERTEBRAE; EFFECT OF IMAGE- BASED MATERIAL PROPERTY ASSIGNMENT METHODS
- DOI:
10.1016/s0021-9290(08)70275-6 - 发表时间:
2008-07-01 - 期刊:
- 影响因子:
- 作者:
Nagitha Wijayathunga;Alison Jones;Robert Oakland;Richard Hall;Ruth Wilcox - 通讯作者:
Ruth Wilcox
FE MODELS OF AUGMENTED HUMAN VERTEBRAE; EFFECT OF ASSIGNING BULK PROPERTIES FOR INJECTED CEMENT
- DOI:
10.1016/s0021-9290(08)70280-x - 发表时间:
2008-07-01 - 期刊:
- 影响因子:
- 作者:
Nagitha Wijayathunga;Alison Jones;Robert Oakland;Richard Hall;Ruth Wilcox - 通讯作者:
Ruth Wilcox
257 - ASSESSMENT OF FLUID INGRESS INTO THE GRAFT-HOST INTERFACE OF OSTEOCHONDRAL GRAFTS IN THE KNEE, USING AN OVINE MODEL
257 - 利用绵羊模型评估膝关节骨软骨移植物的移植物-宿主界面的液体侵入情况
- DOI:
10.1016/j.joca.2025.02.260 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:9.000
- 作者:
Lara S. Esquivel;Gavin Day;Marlène Mengoni;Hazel Fermor;Ruth Wilcox - 通讯作者:
Ruth Wilcox
Ruth Wilcox的其他文献
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{{ truncateString('Ruth Wilcox', 18)}}的其他基金
Innovating Medical Technologies across the Yorkshire Region
约克郡地区的创新医疗技术
- 批准号:
EP/Y023889/1 - 财政年份:2024
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Enabling Individualised Surgical Treatment of Osteoarthritis
实现骨关节炎的个体化手术治疗
- 批准号:
EP/W003139/1 - 财政年份:2022
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Novel design analysis tools to increase precision and reduce variation in hip replacement performance
新颖的设计分析工具可提高精度并减少髋关节置换性能的变化
- 批准号:
EP/N02480X/1 - 财政年份:2016
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Optimising knee therapies through improved population stratification and precision of the intervention
通过改善人群分层和干预精度来优化膝关节治疗
- 批准号:
EP/P001076/1 - 财政年份:2016
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
ULTRASPINE: Ultrasound-Enabled Minimally Invasive Disc Replacement
ULTRASPINE:超声微创椎间盘置换术
- 批准号:
EP/K020757/1 - 财政年份:2013
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Engineering solutions to back pain: an interdisciplinary approach
背痛的工程解决方案:跨学科方法
- 批准号:
EP/F010575/1 - 财政年份:2008
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Calcium phosphate cements for bone augmentation through vertebroplasty
用于椎体成形术增骨的磷酸钙骨水泥
- 批准号:
EP/E022332/1 - 财政年份:2007
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
Optimisation of vertebroplasty to minimise adjacent vertebral failure
优化椎体成形术以尽量减少邻近椎体衰竭
- 批准号:
EP/D002710/1 - 财政年份:2006
- 资助金额:
$ 449.62万 - 项目类别:
Research Grant
相似海外基金
TWINNING: Scalable technologies for creating virtual patient twin populations to accelerate in-silico enabled medical device innovation.
双胞胎:用于创建虚拟患者双胞胎群体的可扩展技术,以加速计算机模拟医疗设备创新。
- 批准号:
10103504 - 财政年份:2024
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$ 449.62万 - 项目类别:
Collaborative R&D
NSERC/McGill Design engineering chair for interdisciplinary innovation of medical technologies
NSERC/McGill 医疗技术跨学科创新设计工程主席
- 批准号:
544190-2018 - 财政年份:2022
- 资助金额:
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MEDTEQ - Quebec Consortium for Industrial Research and Innovation in Medical Technology / Consortium industriel de recherche et d'innovation en technologies médicales du Québec
MEDTEQ - 魁北克医疗技术工业研究和创新联盟 / Consortium industriel de recherche et dinnovation en Technologies mådicales du Québec
- 批准号:
515195-2017 - 财政年份:2022
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- 批准号:
544192-2018 - 财政年份:2022
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MEDTEQ - Quebec Consortium for Industrial Research and Innovation in Medical Technology / Consortium industriel de recherche et d'innovation en technologies médicales du Québec
MEDTEQ - 魁北克医疗技术工业研究与创新联盟 / Consortium industriel de recherche et dinnovation en Technologies médicales du Québec
- 批准号:
515195-2017 - 财政年份:2021
- 资助金额:
$ 449.62万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
NSERC/McGill Design engineering chair for interdisciplinary innovation of medical technologies
NSERC/McGill 医疗技术跨学科创新设计工程主席
- 批准号:
544192-2018 - 财政年份:2021
- 资助金额:
$ 449.62万 - 项目类别:
Chairs in Design Engineering - Research
NSERC/McGill Design engineering chair for interdisciplinary innovation of medical technologies
NSERC/McGill 医疗技术跨学科创新设计工程主席
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544190-2018 - 财政年份:2021
- 资助金额:
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Chairs in Design Engineering - Research
MEDTEQ - Quebec Consortium for Industrial Research and Innovation in Medical Technology / Consortium industriel de recherche et d'innovation en technologies médicales du Québec
MEDTEQ - 魁北克医疗技术工业研究与创新联盟 / Consortium industriel de recherche et dinnovation en Technologies médicales du Québec
- 批准号:
515195-2017 - 财政年份:2020
- 资助金额:
$ 449.62万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
NSERC/McGill Design engineering chair for interdisciplinary innovation of medical technologies
NSERC/McGill 医疗技术跨学科创新设计工程主席
- 批准号:
544190-2018 - 财政年份:2020
- 资助金额:
$ 449.62万 - 项目类别:
Chairs in Design Engineering - Research
NSERC/McGill Design engineering chair for interdisciplinary innovation of medical technologies
NSERC/McGill 医疗技术跨学科创新设计工程主席
- 批准号:
544192-2018 - 财政年份:2020
- 资助金额:
$ 449.62万 - 项目类别:
Chairs in Design Engineering - Research