Investigation of Anarchin, a novel protein family member regulating T cell development and autoimmunity

这个项目的目的是了解免疫系统发展的两个最重要的途径，即T细胞的发展和对自身蛋白的自身反应性的预防。这是由于发现了一种被称为无政府状态的小鼠品系，由于一种以前未被描述的名为无政府状态的基因突变，这种基因在这些途径中存在缺陷。无政府蛋白基因在小鼠和人类中是相似的，是一个功能未知的新基因家族的第一个成员。在这个项目中，我们将发现Anarchin通常如何调节T细胞的选择，产生抗感染的免疫，但防止自身免疫。对感染和自身免疫性疾病（如类风湿关节炎和胰岛素依赖型糖尿病）的免疫力低下，给全世界的人类健康造成了重大负担。因此，安那其宁的发现创造了一个重要的机会来确定治疗这些疾病的新目标。

The aim of this project is to understand two of the most important pathways in the development of the immune system, which are the development of T cells and the prevention of autoreactivity against self-proteins. This is made possible by the discovery of a mouse strain called anarchy with defects in these pathways, due to mutation in a previously uncharacterised gene called Anarchin. The Anarchin gene is similar in mice and humans and is first member of a new gene family with unknown functions. In this project we will discover how Anarchin normally regulates the selection of T cells, generating immunity against infections but preventing autoimmunity. Poor immunity against infections and autoimmune diseases, like rheumatoid arthritis and insulin-dependent diabetes, place a major burden on human health worldwide. Therefore the discovery of Anarchin creates an important opportunity to identify new targets for the treatment of such conditions.