An investigation into the role of DOCK8 in adaptive immunity

DOCK8在适应性免疫中的作用研究

• 批准号: G0901117/1
• 负责人: Richard Cornall
• 金额: $ 60.5万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901117%2F1
• 关键词: investigation; into; role; DOCK8; adaptive

The aim of this project is to understand the role of a novel protein called DOCK8 in the development of immunity to infections. The normal immune response to a vaccine or infection depends on the formation and co-ordinated movement of white blood cells, but we have found that these processes are disrupted when DOCK8 is deficient. In particular, we have found that DOCK8 is required for the survival of the while blood cells that are being selected as part of an antibody response. Our study aims to discover how DOCK8 has such a specific effect on the immune response to vaccines and if these effects may generalized to other processes. The work will help to identify the biological processes underlying the response to vaccines and infections. This is potentially important for the control of human disease, and DOCK8 itself is a potential target for drugs that could suppress the human immune response during inflammation or transplant rejection. Our results from this project will be communicated to the public through Oxford University, websites and other media.

该项目的目的是了解一种新型蛋白质Dock8在感染免疫中的作用。对疫苗或感染的正常免疫反应取决于白细胞的形成和协调运动，但我们发现当DOCK8不足时，这些过程会破坏。特别是，我们发现Dock8是在选择作为抗体反应一部分的同时血细胞存活所必需的。我们的研究旨在发现Dock8如何对疫苗的免疫反应产生如此特殊的影响，以及这些影响是否可以推广到其他过程。这项工作将有助于确定对疫苗和感染反应的基础生物学过程。这对于控制人类疾病至关重要，而DOCK8本身是可以抑制炎症或移植排斥期间人类免疫反应的药物的潜在靶标。该项目的结果将通过牛津大学，网站和其他媒体传达给公众。