Innovative Adaptation & Dissemination of CER Products: Autism(iADAPT-ASD)

描述(由申请人提供)：自闭症和自闭症谱系障碍(ASD)是60多年前首次描述的弥漫性神经发育障碍，根据社交、交流、认知和行为功能的严重损害进行诊断。症状持续一生，扰乱家庭，导致严重残疾；因此，自闭症对公共卫生构成重大挑战。关于哪种干预策略最有效，目前还没有治愈方法，也没有全球共识，通常需要进行长期治疗。鉴于ASD及其相关治疗的复杂性，很明显，教师、临床医生和家庭在选择适当的治疗方法方面需要指导。我们建议增加两种参照ASD疗法的AHRQ比较有效性(CER)产品的影响、使用和应用，调整它们的内容和交付机制，以提高它们在卫生和教育系统、临床实践、照顾者和家庭层面的渗透率、影响和使用。我们的多学科团队汇集了南加州大学电影艺术学院、安纳伯格传播与新闻学院和罗西尔教育学院的教职员工，他们拥有覆盖全国的ASD治疗专家网络。我们的集体专长是在学院获奖纪录片制作、健康传播、定量评估以及行为和药物ASD治疗方面。我们将开发、实施和评估高互动性和参与性的循证干预措施，作为CER产品的定制，针对原始CER审查产品尚未具体针对或触及的重要受众、公共系统和环境。我们将特别针对16,000多名利益攸关方的重要临床医生、家长和教师受众，其中包括：(1)互动自闭症网络(IAN)中10,000名ASD儿童家长的全国样本；(2)难以接触到的350名ASD儿童父母的人群，他们主要来自费城传统上服务不足的少数族裔群体；(3)在南加州三个大型公立学区与ASD儿童有接触的4,000名教师(超过一半来自少数族裔人口)；以及(4)在宾夕法尼亚州公共福利部的赞助下治疗ASD的2,000名获得医疗补助许可的临床医生。我们将通过以技术为基础的传播渠道和社交网络传播渠道，采用新颖的适应方法和创新机制，创作互动性强、情感丰富的纪录片，可以从互联网网站快速轻松地下载。我们的传播方法将包括干预前和干预后的暴露，以定量评估我们干预在目标受众中的效果和影响。我们在内容和交付方面的新方法将加强以加速格式转换新的自闭症科学证据，并将这些证据整合到家庭、教育系统、卫生保健系统和公共政策的实践和决策中。所有工作成果都将与科学界广泛分享。 公共卫生相关性：我们将开发、实施和评估高度互动和引人入胜的循证干预措施，以向16,000多名重要临床医生、家长和教师受众传播自闭症和自闭症谱系障碍的治疗信息。我们与一个面向家长的社交网站、公立学区和一个州医疗保健提供系统合作。我们在内容和交付方面的新方法将加快ASD疗法新科学证据的转化，并将其整合到家庭、教育系统、卫生保健系统和公共政策的实践和决策中。

DESCRIPTION (provided by applicant): Autism and autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders first described over sixty years ago and diagnosed on the basis of significant impairments in social, communicative, cognitive and behavioral functioning. Symptoms persist throughout life, disrupt families and lead to significant disability; thus, ASD presents major public health challenges. There is no cure and no global consensus regarding which intervention strategy is most effective, with chronic management often being required. Given the complexity of ASD and associated therapies, it is clear that teachers, clinicians and families need guidance in selecting appropriate treatments. We propose to increase the impact, use and application of two AHRQ comparative effectiveness (CER) products that reference ASD therapeutics, adapting both their content and delivery mechanism to improve their penetration, impact and use at the health and educational systems, clinical practice, caregiver and family levels. Our multidisciplinary team brings together faculty from the School of Cinematic Arts, Annenberg School for Communication & Journalism and Rossier School of Education at the University of Southern California with a nationwide network of experts on ASD therapeutics. Our collective expertise is in academy award-winning documentary film production; health communication; quantitative evaluation; and behavioral and pharmacologic ASD treatments. We will develop, implement, and evaluate highly interactive and engaging evidence-based interventions as customizations of CER products that target important audiences, public systems and settings that are not already specifically targeted or reached by the original CER review products. We specifically will target important clinician, parent and teacher audiences of over 16,000 stakeholders that include: (1) a nationwide sample of 10,000 parents of ASD children in the Interactive Autism Network (IAN); (2) a difficult-to-reach population of 350 parents of ASD children, primarily from traditionally underserved minority groups in the city of Philadelphia; (3) 4,000 teachers (over half from minority populations) in three large Southern California public school districts who have contact with ASD children; and (4) 2,000 Medicaid-licensed clinicians across Pennsylvania who treat ASD under the auspices of the Department of Public Welfare. We will employ novel methods of adaption and innovative mechanisms through technology-based and social networking dissemination channels to create highly interactive and emotionally engaging documentary vignettes that can be rapidly and easily downloaded from an internet website. Our dissemination approach will incorporate pre- and post- intervention exposure to quantitatively evaluate the efficacy and impact of our intervention in the targeted audiences. Our novel approaches to both content and delivery will enhance the translation of new scientific ASD evidence in an accelerated format and the integration of this evidence into practice and decision-making in families, the education system, the health care system and public policy. All work products will be broadly shared with the scientific community. PUBLIC HEALTH RELEVANCE: We will develop, implement, and evaluate highly interactive and engaging evidence-based interventions for disseminating information about treatments for autism and autism spectrum disorders to over 16,000 individuals in important clinician, parent and teacher audiences. We partner with a social networking site for parents, public school districts and a state healthcare delivery system. Our novel approaches to both content and delivery will enhance the translation of new scientific evidence on ASD therapeutics in an accelerated format and its integration into practice and decision-making in families, the education system, the health care system and public policy.