FASEB Summer Conference on Protein Phosphatases

描述（由申请人提供）：通过蛋白磷酸化进行的翻译后修饰可能是最常见的生物调节机制，蛋白磷酸酶是控制该过程的关键且复杂的酶。本申请请求对第十届及随后的FASEB蛋白磷酸酶夏季研究会议的持续支持，同时也是对蛋白酪氨酸磷酸酶鉴定20周年的认可。这个一年两次的会议是北美关于这个主题的主要会议，为实验生物学家提供了一个亲密的环境，以探索和讨论当前蛋白磷酸酶研究的前沿领域及其在生命调节中的重要作用。磷酸酶在癌症、干细胞、糖尿病和代谢紊乱中的作用的重大进展将在会议上得到强调。我们的会议将包括癌症，糖尿病，神经系统疾病，传染病和发育异常，蛋白磷酸酶发挥关键作用的所有领域的会议。 会议的具体目标是： (1)介绍蛋白磷酸酶的结构、调节和功能的最新研究进展。将特别注意这些酶的不同生理和病理生理作用，阐明了在哺乳动物和其他真核生物系统中使用不同的方法。 (2)通过分别使用开幕式和主题演讲，突出该领域的主要成就和新出现的机会。 (3)通过从提交的摘要中选择大量演讲者并邀请在该领域取得新进展的人投稿，鼓励招聘和培养该领域的新科学家和年轻科学家，特别是初级教师、妇女和代表性不足的少数民族。

DESCRIPTION (provided by applicant): Post-translational modification by protein phosphorylation is perhaps the most common biological regulatory mechanism, and protein phosphatases are key and complex enzymes that control this process. This application requests ongoing support for the Tenth and subsequent FASEB Summer Research Conferences on Protein Phosphatases, also recognizing the 20th anniversary of the identification of protein tyrosine phosphatases. This bi-annual meeting, the major North American meeting on this topic, provides an intimate environment for experimental biologists to explore and discuss cutting edge areas of current research on protein phosphatases and their important role in regulation of life. Major advances in the role of phosphatases in cancer, stem cells, diabetes, and metabolic disorders will be highlighted at the meeting. Our conference will include sessions on cancer, diabetes, neurological disorders, infectious diseases and developmental abnormalities, all areas where protein phosphatases play critical roles. The Specific Aims of the conference are: (1) To present the most current work on the structure, regulation and function of the protein phosphatases. Particular attention will be paid to the diverse physiological and pathophysiological roles of these enzymes, as elucidated by the use of diverse approaches in mammalian and other eukaryotic systems. (2) To highlight major achievements and emerging opportunities in the field through the use of Opening and Keynote Lectures, respectively. (3) To encourage the recruitment and development of new and young scientists in the field, especially junior faculty, women and under-represented minorities, by selecting a significant number of speakers from the submitted abstracts and inviting contributions from those making novel advances in the field.