FACULTY DVMT & CLIN BEHV RES CORES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 引言 该中心的活动已按照我们最初计划的建议进行。最初提出的所有研究项目(3)都处于最后阶段，在过去一年中向几个试点项目提供了发展资金。总共有9个正在进行或正在进行的项目。我们将提交一份建议，再提供一年的部分资助(“过渡期”)，以使中心能够继续开展NCRR认为合适的续签或进一步资助活动。 我们列出了该中心的主要研究人员和教职员工发表的28种科学出版物。作为本报告的一部分，我们将介绍以下核心小组的活动：学院发展和进步评估核心、数据核心和数据管理系统、内部和外部咨询委员会以及实验室核心。包括一份关于发展研究项目的报告。 二、中心的具体目标 在第一个供资周期结束时，我们完成了该中心的所有具体目标如下： 1.建立一个综合中心，目的是通过三所经认证的公共关系医学院、公共卫生学院和牙科学校之间的合作努力，加强波多黎各的临床和转化性研究能力，以建立合作的“传统” PR-CCHD成功地建立并留住了PR的三所经认证的医学院以及其他几个项目的合作者，总共增加了六所专业学校。UPR公共卫生学院、UPR牙科学院、庞塞医学院临床心理学方案、Nova东南药房学院和Iniciativa Comunitaria de Investigacion(ICI-西班牙语首字母缩写)都是合作者的一部分。因此，在第一个供资周期内，合作专业学校的数量从最初的三所增加到六所和一个社区组织(CBO)。 鼓励初级调查人员建立机构间伙伴关系和研究团队，中心提供的指导和基础设施支持加强了这一活动。 这是一个独特的创新中心，因为它明确建立了一种合作研究机制，将每个参与机构的主要活动整合到一个中心概念中：数据中心、实验室和临床研究中心。尽管一体化和协作一直是许多倡议的目标，但真正的协作研究是通过资源的网络建立起来的，是一种传统，而不是一个孤立的事件。这种(合作的传统或文化)可能是这项提议最大、最重要的长期成就之一。这一合作传统始于首席调查人员，但初级调查人员的长期参与将巩固这一传统，他们将以不同的模式开始他们的职业生涯：即使在“相互竞争的”机构内也可以进行成功的合作。这将使所有相关各方受益。 2.制定针对波多黎各人口的可持续、可复制和文化上适当的预防和/或干预研究方案，以减轻疾病负担。 作为该中心活动的一部分，制定了几项预防干预措施，其中最突出的是发展拉美裔/拉丁裔方面(一种使用快速艾滋病毒检测的降低风险干预措施)。 3.开发和验证一系列适合文化的工具，以衡量各种变量，例如但不限于：社会人口、艾滋病毒危险行为、共病、坚持、污名、暴力和虐待历史；并向感兴趣的调查人员和保健提供者提供这些工具。 开发了各种工具，以充分衡量艾滋病毒/艾滋病高危人群中感受到的耻辱以及虐待和忽视。 4.增加岛上机构与在美国本土有较成熟研究项目的机构之间开展多学科研究合作的机会。 启动了与诺瓦东南大学和其他项目的合作。 5.利用本地和国外(公关和美国机构)的资源，为初级调查人员建立导师方案，并创造激励的学术环境，鼓励学生和研究员从事健康差距研究，特别是艾滋病毒/艾滋病研究。 根据过去四年开展的培训和发展活动的成果和影响，我们制定了一个指导/教育框架。一篇分析文章发表在《美国公共卫生杂志》上。(拉比昂特，S，圣地亚哥，L，佐里拉，C.，2009年，第99卷，编号S1 65-70)。 除上述活动外，另一个合作伙伴也参与了研究活动：调查委员会是一个以社区为基础的组织，成立于1991年，向受艾滋病毒/艾滋病影响的人提供全面的初级和二级预防和支助服务。它起源于由美国国立卫生研究院资助的CPCRA(社区参与式临床研究活动)，将研究活动带到社区。ICI为普通人群提供服务，特别关注边缘化群体，如无家可归者、吸毒者和从事商业性工作者(以性换取毒品/金钱)的妇女。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction The activities of the Center have been carried out as proposed in our original plan. All of the originally proposed research projects (3) are during their last stages and developmental funding was provided to several pilot projects during the past year. In total there are 9 ongoing or active projects. We will be submitting a proposal for an additional year of partial funding ("bridge") to allow the Center to continue activities towards renewal or further funding as deemed advisable by the NCRR. We are including a list of 28 scientific publications from the key investigators and faculty involved in the Center. As part of this report we are describing the activities of the Core groups: the Faculty Development and Progress Evaluation Core, the Data Core and DSMB, both Internal and External Advisory Committees and the Laboratory Core. A report on the developmental research projects is included. II. Specific Aims of the Center At the end of the first funding cycle we completed all of our specific aims for this Center as follows: 1.To establish a Comprehensive Center with the purpose of enhancing the clinical and translational research capabilities in Puerto Rico through a collaborative effort between the three accredited Medical Schools in PR, the UPR School of Public Health and the UPR School of Dentistry to establish a "tradition" of collaboration The PR-CCHD was successful in establishing and retaining collaborators from the three accredited medical schools in PR plus several other programs adding to a total of six professional schools. The UPR School of Public Health, the UPR School of Dentistry, the Ponce School of Medicine Program of Clinical Psychology, the NOVA Southeastern School of Pharmacy and Iniciativa Comunitaria de Investigacion (ICI-Spanish acronym) were included as part of the collaborators. So, during the first funding cycle, the number of collaborating professional schools increased from the original three to six and one Community Based Organization (CBO). The junior investigators were encouraged to establish inter-institutional partnerships and research teams and this activity was enhanced by the mentoring and infrastructure support provided by the center. This is a unique and innovative Center since it clearly establishes a mechanism for collaborative research that integrates into one central concept the salient activities at each participating institution: a Data Center, a Laboratory and a Clinical Research Center. Although integration and collaboration has been the target of many initiatives, it is through the webbing of resources that true collaborative research was established as a tradition and not as an isolated event. This (tradition or culture of collaboration) will perhaps be one of the biggest and most important long-term accomplishments of this proposal. This tradition of collaboration stared with the lead investigators, but will be cemented by the long-term participation of junior investigators who will initiate their careers with a different paradigm: that successful collaboration can happen even within "competing" institutions. This will be in the benefit of all involved. 2. To develop sustainable, replicable and culturally appropriate prevention and/or intervention research programs targeted to the Puerto Rican population to decrease the burden of disease. Several prevention interventions were developed as part of the activities of the center, the most salient was the development of the Hispanic/Latino Respect (a risk reduction intervention using the rapid HIV test). 3. To develop and validate a series of culturally appropriate instruments to measure diverse variables such as but not limited to: socio-demographic, HIV risk behaviors, co-morbidities, adherence, stigma, history of violence and abuse; and to make them available to interested investigators and health care providers. Instruments were developed to adequately measure perceived stigma as well as abuse and neglect among populations at-risk for HIV/AIDS. 4. To enhance the opportunities for multidisciplinary research collaborations between the island institutions and those with a more established research programs in the US mainland. Collaborations with NOVA Southeastern University and other programs were initiated. 5. To establish a Mentorship program for junior investigators with resources from both local and abroad (PR and US institutions) and to create the stimulating academic environment that will encourage students and fellows to pursue a career in health disparities research and in particular, HIV/AIDS research. Based on the outcomes and the impact of the training and development activities performed in the last four years, we developed a mentoring/educational framework. An analytic essay/article was published in the American Journal of Public Health. (Rabionet, S, Santiago, L, and Zorrilla, C. 2009, Vol 99, No S1 65-70). In addition to the previously mentioned activities, another partner was included in the research activities: Iniciativa Comunitaria de Investigacion (ICI) is a community-based organization established in 1991 to provide comprehensive primary and secondary prevention and support services to people affected with HIV/AIDS. It originated from the CPCRA (Community Participatory Clinical Research Activities) funded by NIH to bring research activities to the community. ICI serves the general population with special attention to marginalized groups such as, homeless, drug addicts, and women who engage in commercial sex worker (sex for drugs/money).