PROJECT 1- CHEMICAL BIOLOGY OF ARISTOLOCHIC ACIDS

在进度报告中。重要的是，所采用的合成路线通常是 适用于将马兜铃酸-L(AA-1)等AA衍生的加合物掺入DNA 类比。 专家小组还评论说，进度报告没有涉及以前的目标……人们对……感到担忧 采取成功的协调一致的方法的能力。实现了原提案的目标2和目标3 如进度报告所述，正在积极开展工作，但没有出版出版物。在目标2的情况下， Lexitropsins的选择性不能在寡聚DNA水平上重现。目标3的前提； 双酚A的氧化产物是其诱变行为的原因，这一点无法得到证实。 因此，我们转向了一个与PPG研究的长期目标直接相关的项目，在 苯并茂二醇环氧化物加合物的新引入方法

in the Progress Report. Importantly, the synthetic route employed is generally applicable to the incorporation into DNA of adducts derived from aristolochic acid-l (AA-1) and other AA analogs. The Panel also commented that the progress report does not address previous aims ... there is concern about the ability to mount a successful concerted approach. Aims 2 and 3 of the orginal proposal were pursued actively, as described in the Progress Report, but did not result in publications. In the case of Aim 2, the selectivity of the lexitropsins could not be reproduced at the level of oligomeric DNA. The premise of Aim 3; that oxidation products of bisphenol A are responsible for their mutagenic behaviour, could not be confirmed. We therefore turned to an project directly related to the long-term goals of this PPG research and, in developing a novel method for introducing benzpyrenediolepoxide adducts