Training in Orthopaedic and Musculoskeletal Clinical Research

描述（由申请人提供）：肌肉骨骼和骨科疾病非常普遍，致残和昂贵。然而，由于缺乏训练有素的临床和转化研究人员的强大管道，对这些疾病的研究受到阻碍。只有6%的NIAMS资助的T32项目专注于骨科和肌肉骨骼临床和转化研究。这项拟议的T32培训补助金的目标是为博士前和博士后候选人提供严格的临床，转化，流行病学和政策研究培训计划，涉及肌肉骨骼和骨科疾病，包括其预防，识别，负担和影响，以及手术和非手术治疗。研究领域涵盖肌肉骨骼疾病，包括骨关节炎、骨质疏松症、骨科干预、区域疾病（例如脊柱、膝关节、肩关节、上肢、足/踝关节）、神经卡压、慢性肌肉骨骼疼痛和相关疾病。该计划将支持一系列学科的培训，包括流行病学，生物统计学，药物流行病学，索赔分析，决策科学，经济分析，差异检查以及心理和行为干预。该申请要求资助两个博士前和三个博士后培训职位。受训者将在该项目中至少呆两年。那些事先没有接受过正式教学培训的人将在哈佛公共卫生学院的临床有效性项目中获得硕士学位。该计划提供了密切的监督和机会，跨学科的工作与优秀的研究人员和导师从几个哈佛医疗机构的教师。教师们得到了联邦、基金会和其他方面的资助。每个教师都有成功的指导记录，每个领导充满活力的研究团队从事广泛的实质性领域和方法学科。这些机构以病人来源、大量电子和硬拷贝图书馆、先进的信息系统和数据库资源的形式提供了相当大的支持。该申请旨在寻求资金，以培训年轻人成为研究肌肉骨骼和骨科问题的领先科学家。这些疾病非常常见，致残，昂贵和研究不足。

DESCRIPTION (provided by applicant): Musculoskeletal and orthopaedic disorders are exceptionally prevalent, disabling and costly. However research on these conditions is hampered by the lack of a robust pipeline of rigorously trained clinical and translational researchers. Just 6% of NIAMS funded T32 programs have a focus in orthopaedic and musculoskeletal clinical and translational research. The objectives of this proposed T32 training grant are to provide pre- and postdoctoral candidates with a rigorous program of training in clinical, translational, epidemiological and policy research involving musculoskeletal and orthopaedic disorders, including their prevention, recognition, burden and impact, and operative and nonoperative treatment. The research areas span the musculoskeletal disorders, including osteoarthritis, osteoporosis, orthopaedic interventions, regional disorders (e.g. spine, knee, shoulder, upper extremity, foot/ankle), nerve entrapments, chronic musculoskeletal pain and related conditions. The program will support training in a range of disciplines including epidemiology, biostatistics, pharmacoepidemiology, claims analysis, decision sciences, economic analysis, examination of disparities, and psychosocial and behavioral interventions. This application requests funding for two predoctoral and three postdoctoral training positions. The trainees would spend at least two years in the program. Those without prior formal didactic training will obtain master's level education in the Clinical Effectiveness Program at Harvard School of Public Health. The Program provides close supervision and opportunities to work across disciplines with a faculty of outstanding investigators and mentors from several Harvard medical institutions. The faculty members are well funded with federal, foundation and other support. Each faculty member has a record of successful mentoring and each leads vibrant research teams engaged in a wide range of substantive areas and methodological disciplines. The institutions provide considerable support in the form of patient sources, vast electronic and hard copy libaries, sophisticated information systems and database resources. Lay summary: This application seeks funds to train young people to become leading scientists studying musculoskeletal and orthopaedic problems. These disorders are very common, disabling, expensive and understudied.