Radiation biology training grant

描述（由申请人提供）：这是一份培训资助计划的竞争性更新申请，旨在培训具有辐射分子、细胞和组织效应知识的辐射生物学家。招收博士预科生6人，博士后培养4人。培训将在宾夕法尼亚大学医学院肿瘤研究部门的放射生物学和相关实验室提供。该计划将包括正式的课程，系列讲座和为我们的培训需求而设计的期刊俱乐部，研究研讨会和会议以及由既定调查员监督的实验室研究项目。研究项目将集中在参与实验室目前获资助研究领域的各个方面；在研究项目方面，学员将利用现代生物学发展的技术进行辐射生物学/肿瘤学方面的机械导向研究。这14位培训导师所涉及的研究领域广泛涉及癌症研究，包括致癌和诱变的分子机制、分子和细胞辐射生物学、辐射化学和生物化学、DNA修复过程、癌症预防和放射肿瘤学。预计该培训计划的毕业生将继续他们在放射生物学和肿瘤学方面的研究和学术生涯。

DESCRIPTION (provided by applicant): This is a competitive renewal of a training grant proposal for a program designed to train radiation biologists who will have knowledge of the molecular, cellular and tissue effects of radiation. 6 predoctoral and 4 postdoctoral trainees are requested. Training will be offered in the radiation biology and associated laboratories of the Division of Oncology Research at the University of Pennsylvania School of Medicine. The program will involve formal coursework, a lecture series and a journal club designed for our training needs, research seminars and conferences and laboratory research projects to be supervised by established investigators. The research projects will focus on various aspects of the currently funded research areas in the participating laboratories; for research projects, trainees will utilize techniques developed in modern biology to perform mechanistically-oriented studies in radiation biology/oncology. The research areas in which the 14 training preceptors are involved are broadly based in cancer research, including molecular mechanisms of carcinogenesis and mutagenesis, molecular and cellular radiation biology, radiation chemistry and biochemistry, DNA repair processes, cancer prevention and radiation oncology. It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology.