DEVELOPMENT OF A NEW PSA ASSAY FOR PROSTATE DISEASE
开发前列腺疾病的新 PSA 检测方法
基本信息
- 批准号:2863387
- 负责人:
- 金额:$ 9.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-07-01 至 2000-12-01
- 项目状态:已结题
- 来源:
- 关键词:benign prostate hyperplasia bioassay chymotrypsin inhibitor diagnosis design /evaluation diagnostic tests enzyme linked immunosorbent assay male reproductive system disorder diagnosis monoclonal antibody prostate disorder prostate neoplasms prostate specific antigen serology /serodiagnosis technology /technique development
项目摘要
DESCRIPTION: (Adapted from the applicant's abstract) This Phase I STTR
addresses the significance of changes in the serum levels of prostate specific
antigen (PSA) in prostate diseases and also intends to develop and determine
the sensitivity and specificity of a new PSA assay (NPSAA) that is expected to
help distinguish between prostate diseases (with emphasis on distinguishing
between benign prostatic hyperplasia (BPH) and prostate cancer). A battery of
monoclonal antibodies (MAbs) capable of distinguishing the free form of human
PSA from the complex formed between PSA and a plasma protease inhibitor,
a-l-antichymotrypsin (ACT) have been developed and will be utilized for studies
proposed. It is expected that the NPSAA kit to be developed will be
particularly useful in distinguishing prostate cancer from BPH when the serum
PSA concentration is slightly above normal, in the range of 4-10 ng/ml; in this
range, the conventional methods for measuring PSA levels are not useful for
determinations of the type of prostate disease present.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
描述:(改编自申请人摘要)本I期STTR
解决了前列腺特异性抗体血清水平变化的意义,
抗原(PSA)在前列腺疾病,也打算开发和确定
一种新的PSA检测(NPSAA)的灵敏度和特异性,预计将
有助于区分前列腺疾病(重点是区分
良性前列腺增生(BPH)和前列腺癌之间)。的电池
单克隆抗体(MAb)能够区分游离形式的人类
PSA来自PSA和血浆蛋白酶抑制剂之间形成的复合物,
已开发出α-l-抗胰凝乳蛋白酶(ACT),并将用于研究
提出了预计将开发的NPSAA工具包将
特别适用于区分前列腺癌和BPH,
PSA浓度略高于正常值,在4 - 10 ng/ml的范围内;在此情况下,
由于PSA水平的范围很小,因此测量PSA水平的常规方法对于
前列腺疾病的类型的确定。
拟议商业应用:不可用
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Three immunoassays based on monoclonal antibodies specific for prostate specific antigen (PSA), alpha-1-antichymotrypsin (ACT), and the PSA-ACT complex.
三种免疫测定基于前列腺特异性抗原 (PSA)、α1-抗胰凝乳蛋白酶 (ACT) 和 PSA-ACT 复合物的特异性单克隆抗体。
- DOI:10.1002/pros.10247
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Wan,XSteven;Xu,YAnne;Ware,JeffreyH;Kennedy,AnnR
- 通讯作者:Kennedy,AnnR
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ANN R KENNEDY其他文献
ANN R KENNEDY的其他文献
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{{ truncateString('ANN R KENNEDY', 18)}}的其他基金
IN VITRO SCREENING OF POTENTIAL CHEMOPREVENTIVE AGENTS
潜在化学预防剂的体外筛选
- 批准号:
6096052 - 财政年份:1999
- 资助金额:
$ 9.91万 - 项目类别:
PSA ASSAY TO DISTINGUISH BETWEEN PROSTATE DISEASES
PSA 检测可区分前列腺疾病
- 批准号:
2010479 - 财政年份:1996
- 资助金额:
$ 9.91万 - 项目类别:
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