Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)

描述（由申请人提供）：本提案是为K23指导的患者导向的研究职业发展奖，将准备候选人在转化神经认知研究的成功独立的职业生涯。候选人和他的导师在UT西南医学中心（UTSW）和哥伦比亚大学/纽约州立精神病研究所（CU/NYSPI）设计了一个阶段指导和安排过渡（SMART）职业发展途径，使他成为一个熟练的，独立的研究者在神经认知功能，情绪障碍和神经刺激干预的交叉点工作。这种独特的研究利基将允许候选人利用他的导师的专业知识，同时建立他作为独立调查员的个人身份。SMART途径形成了一个由专家导师和顾问组成的合作网络（Mustafa M.作者：Sarah H. Lisanby角Munro Cullum、Herb Terrace、伊拉伯恩斯坦、乔治·阿列索普洛斯和哈罗德A.平卡斯）。职业发展计划包括学术教学和研讨会，专家指导，在UTSW和CU/NYSPI的实践经验，以及有形的生产力，包括同行评审的手稿和赠款申请。候选人的职业道路的独特之处在于，在此授予期间，主要任命从UTSW到CU/NYSPI的预先计划的转变。这将有助于他实现过渡目标，并使他顺利过渡到独立地位。他的研究项目的目标是开发和进行转化研究评估神经认知记忆过程（TREC-MP）。使用模型动物来研究神经认知功能已被广泛用于基础科学方法。然而，由此产生的临床人类使用的应用受到限制。TREC-MP是一个翻译项目，检查人类的实验计算机神经认知措施的心理测量特性，这些措施是为接受电惊厥休克和磁癫痫治疗的非人灵长类动物开发的。这项增量研究旨在优化健康人群中的实验性神经认知电池，然后确定抑郁症对测试表现的影响，最后确定接受电休克治疗（ECT）的抑郁症受试者的神经认知表现。ECT的认知影响是公认的，具有相当大的临床意义，但什么是不太好理解的是抑郁症和ECT的认知组件过程之间的复杂的相互作用。因此，需要更新的认知评估方法来阐明跨物种的相似和不同的认知过程，并确定接受ECT的患者记忆障碍的潜在认知成分过程。正如最近的NIMH转化神经认知研究和临床倡议所示，一个有用的策略是发展比较非人类灵长类动物和人类神经认知措施，用于特定的神经认知领域和组件过程。一个特定的神经认知电池的应用，预测基础科学的神经认知研究与非人灵长类动物提供了一个强大的方法来了解记忆缺陷的认知组件的过程，从而允许未来的发展有针对性的治疗干预措施和有用的临床神经认知措施。[The该项目的目标是：1）开发和验证用于健康人类参与者的实验神经认知测量，2）确定抑郁对实验神经认知测量表现的影响，以及3）确定ECT对实验神经认知测量表现的影响。将采用经典测验和项目反应理论统计进行分析。该项目具有科学创新性和重要性，因为它将为候选人提供一个平台，进行转化神经认知研究，帮助他了解记忆障碍的病因，并最终设计适当的临床神经认知措施和干预措施。候选人的SMART途径和TREC-MP项目为他作为独立的翻译神经认知科学家的个性化和系统化发展奠定了基础。 公共卫生相关性：与严重抑郁症的精神科治疗相关的认知功能受损导致功能结局不良。这个职业发展奖的目标是让候选人成为一名熟练的翻译神经认知科学家。长期目标是这项转化神经认知研究，以提供一个更清晰的认知组成过程，强调认知功能障碍，以制定心理测量健全的神经认知结果的措施和有针对性的治疗干预措施。

DESCRIPTION (provided by applicant): This proposal is for a K23 Mentored Patient Oriented Research Career Development Award that will prepare the candidate for a successful independent career in translational neurocognitive research. The candidate and his mentors at UT Southwestern Medical Center (UTSW) and Columbia University/New York State Psychiatric Institute (CU/NYSPI) designed a Staged Mentored and Arranged Transition (SMART) career development pathway to enable him to become a proficient, independent investigator working at the intersection of neurocognitive function, mood disorders, and neurostimulation interventions. This unique research niche will allow the candidate to leverage the expertise of his preceptors while establishing his individual identity as an independent investigator. The SMART pathway forms a collaborative network of expert mentors and advisors (Drs. Mustafa M. Husain, Sarah H. Lisanby, C. Munro Cullum, Herb Terrace, Ira Bernstein, George Alexopoulos, and Harold A. Pincus). The career development plan is comprised of scholarly didactics and seminars, expert preceptorship, hands-on experience at UTSW and CU/NYSPI, as well as tangible productivity including peer-reviewed manuscripts and grant applications. Unique to the candidate's career path is the pre- planned shift in primary appointment from UTSW to CU/NYSPI during this award period. This will facilitate his transitional goals as well as smooth his transition to independent status. The goal of his research project is to develop and conduct Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP). The use of model animals to study neurocognitive functions has been employed extensively in basic science methodologies. However, the resulting applications for clinical human use have been limited. TREC-MP is a translational project that examines the psychometric properties in humans of experimental computerized neurocognitive measures developed for nonhuman primates undergoing electroconvulsive shock and magnetic seizure therapy. This incremental research study is designed to optimize the experimental neurocognitive battery in a healthy human cohort, then to determine the effects of depression on test performance, and finally to determine the neurocognitive performance of depressed subjects undergoing electroconvulsive therapy (ECT). The cognitive impact of ECT is well recognized and of considerable clinical significance, but what is less well understood is the complex interaction between depression and ECT on cognitive component processes. As such, newer methods of cognitive assessment are needed to elucidate similar and divergent cognitive processes across species, and identify underlying cognitive component processes of memory impairment in patients receiving ECT. As exemplified in recent NIMH translational neurocognitive research and clinical initiatives, one useful strategy would be the development of comparative nonhuman primate and human neurocognitive measures for specific neurocognitive domains and component processes. The application of a specific neurocognitive battery, predicated on basic science neurocognitive research with nonhuman primates provides a powerful method for understanding the cognitive component processes of memory deficits, thereby permitting the future development of targeted treatment interventions and useful clinical neurocognitive measures. [The aims of this project are: 1) Develop and validate experimental neurocognitive measures for use with healthy human participants, 2) Determine effects of depression on performance on experimental neurocognitive measures, and 3) Determine effects of ECT on performance on experimental neurocognitive measures.] Analyses will be conducted with both classical test and item response theory statistics. This project is scientifically innovative and important because it will provide a platform for the candidate to conduct translational neurocognitive research to help him understand the etiology of memory impairment and ultimately design appropriate clinical neurocognitive measures and interventions. The candidate's SMART pathway and TREC-MP project set the stage for his individualized and systematic development as an independent translational neurocognitive scientist. PUBLIC HEALTH RELEVANCE: Impaired cognitive functions associated with psychiatric treatments of severe depression contribute to poor functional outcomes. The objective of this career development award is for the candidate to become a proficient translational neurocognitive scientist. The long-term goal is for this translational neurocognitive research to provide a clearer understanding of the cognitive component processes that underscore cognitive functional impairments in order to develop psychometrically sound neurocognitive outcome measures and targeted treatment interventions.