International Consortium on Fish Toxicogenomics

对自然环境的主要关切之一是污染化学品可能产生的影响，特别是对河流和海洋中的鱼类。我们可以检查鱼是否导致疾病，我们可以寻找可能的污染化学物质，但我们真正需要的是非常敏感的测量，以在为时已晚和疾病或死亡发生之前检测可能有害的微小生物变化。近年来，有了惊人的科学进步，研究人员可以同时观察数千种不同的分子(信使RNA、代谢物和蛋白质)，这告诉我们动物的健康状况。这一生物科学的新领域被称为“组学”。现在，我们希望与世界各地的科学家互动，将我们的想法结合在一起，这样我们就可以找到方法来利用‘组学’方法产生的大量生物信息。我们还希望找出如何利用这些信息来帮助公司和政府了解哪些化学品(如果有的话)正在对环境造成危害，并帮助阻止使用新的有害化学品。我们将举办研讨会，科学家们将决定需要什么以及如何做到这一点，然后工人们将聚集在一起，将其付诸实施。最终，我们将拥有数据库和新的、灵敏的测试方法，以检测化学物质对环境中鱼类的影响。

One of the major concerns for the Natural Environment is the possible effects of polluting chemicals especially in fish within rivers and seas. We can check to see if disease is caused in fish and we can look for possible polluting chemicals but what we really need are very sensitive measurements to detect tiny biological changes that might be harmful before it is too late and disease or death occurs. In recent years there have been fantastic scientific advances that allow researchers to look at thousands of different molecules (messenger RNA, metabolites and proteins) all at the same time and this tells us about the health of the animal in great detail. This new area of biological science is called the 'omics'. We now wish to interact with scientists all over the world to bring our ideas together so that we can find ways to use the enormous amount of biological information that is being produced by the 'omics' methods. We also wish to find out how we can use this information to help companies and the governments to see which chemicals, if any, are causing harm in the environment and to help stop new harmful chemicals from being used. We will have workshops where the scientists will decide on what is needed and how to do it and then workers will come together to put this into action. In the end we will have databases and new, sensitive test methods for detecting effects of chemicals on fish in the environment.