Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.
Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.
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DOI：
10.1289/ehp.0900985
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发表时间：
2010-01
影响因子：
10.4
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Van Aggelen G;Ankley GT;Baldwin WS;Bearden DW;Benson WH;Chipman JK;Collette TW;Craft JA;Denslow ND;Embry MR;Falciani F;George SG;Helbing CC;Hoekstra PF;Iguchi T;Kagami Y;Katsiadaki I;Kille P;Liu L;Lord PG;McIntyre T;O'Neill A;Osachoff H;Perkins EJ;Santos EM;Skirrow RC;Snape JR;Tyler CR;Versteeg D;Viant MR;Volz DC;Williams TD;Yu L
在这篇评论中，我们介绍了由英国自然环境研究理事会赞助的国际鱼类毒理学联盟的研究结果（鱼类毒理学——转向监管和监测，2008年4月21日至23日在加拿大不列颠哥伦比亚省温哥华太平洋环境科学中心举行）。来自政府机构、学术界和工业界的联盟讨论了三个主题：生态毒物基因组学的进展、毒物基因组学在风险评估中实际实施的障碍的监管观点，以及处理数据集的变异性。与会者指出，组学技术成功应用的例子已经确定，但需要进行关键研究来将分子变化与生态不良后果联系起来。与会者就技术和生物变异的管理提出了建议。他们还强调需要加强跨学科培训和交流，以及对适当的参考组学数据的生成和管理进行大量投资。与会者得出的结论是，尽管在获得监管认可的道路上存在障碍，但组学技术已经可用于阐明有毒物质的作用模式，并且可以作为证据权重方法的一部分为风险评估过程做出贡献。
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics—Moving into Regulation and Monitoring, held 21–23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada). The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets. Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data. The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.
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影响因子：
2.7
作者：
Hartung, T;Bremer, S;Zuang, V
通讯作者：
Zuang, V
影响因子：
4.5
作者：
Falciani, F.;Diab, A. M.;Chipman, J. K.
通讯作者：
Chipman, J. K.
影响因子：
11.4
作者：
Bundy, Jacob G.;Keun, Hector C.;Morgan, A. John
通讯作者：
Morgan, A. John
影响因子：
4.1
作者：
Forbes, VE;Palmqvist, A;Bach, L
通讯作者：
Bach, L
影响因子：
4.1
作者：
Miller, David H.;Jensen, Kathleen M.;Ankley, Gerald T.
通讯作者：
Ankley, Gerald T.