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Molecular and genomic ecotoxicology knowledge transfer for environmental chemical risk assessment

Molecular and genomic ecotoxicology knowledge transfer for environmental chemical risk assessment
用于环境化学品风险评估的分子和基因组生态毒理学知识转移
批准号:
NE/D000807/1
负责人:
J Chipman
金额:
$7.6万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2006
资助国家:
英国
项目状态:
已结题
起止时间:
2006 至 --

项目摘要

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中文摘要
翻译
对自然环境的主要关注之一是污染化学品的可能影响,特别是在河流和海洋中。监测和管理环境中化学品水平的行业和政府部门可以检查是否导致鱼类疾病,并可以寻找可能的污染化学品,但我们真正需要的是非常敏感的测量方法,以便在为时已晚和疾病发生之前发现可能对鱼类有害的微小变化。近年来,科学取得了惊人的进步,使研究人员能够同时观察数千种不同的分子(信使RNA,代谢物和蛋白质),这告诉我们动物的健康状况非常详细。生物科学的这个新领域被称为“组学”。该项目涉及与大学和环境局等组织之间的信息转移,以便双方都可以了解如何使用该技术来改善环境中动物健康的评估,并帮助公司和政府了解哪些化学品,如果有的话,我们将举办一个研讨会,科学家们将决定需要什么以及如何做到这一点,然后工人们将在组织之间进行交流,相互学习最后,我们应该有更好的测试方法来检测化学品对鱼类和环境中其他生物的影响。
英文摘要
One the major concerns for the Natural Environment is the possible effects of polluting chemicals especially in rivers and seas. Industry and Government departments that monitor and regulate the levels of chemicals in the environment can check to see if disease is caused in fish and can look for possible polluting chemicals but what we really need are very sensitive measurements to detect tiny changes that might be harmful in fish before it is too late and disease occurs. In recent years there have been fantastic scientific advances that allow researchers to look at thousands of different molecules (messenger RNA, metabolites and proteins)all at the same time and this tells us about the health of the animal in great detail. This new area of biological science is called the 'omics'. This project involves a transfer of information to and from Universities and organisations such as the Environment Agency so that both can learn about how this technology can be used to improve the assessment of animal health in the environment and to help companies and the government to see which chemicals, if any, are causing harm in the environment.We will have a workshop where the scientists will decide on what is needed and how to do it and then workers will exchange between organisations to learn from each other and to put this into action.In the end we should have better test methods for detecting effects of chemicals on fish and other organisms in the environment.
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Distinguishing toxic from adaptive responses in fish using 'omics'- a key need for integration of toxicogenomics into environmental risk assessment.
  • 批准号:
    NE/F008465/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $6.17万
  • 财政年份:
    2008
  • 负责人:
    J Chipman
  • 依托单位:
Genomic and oxidation-related biological responses in fish exposed to fullerenes of different physicochemical characteristics
  • 批准号:
    NE/E014836/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $3.67万
  • 财政年份:
    2007
  • 负责人:
    J Chipman
  • 依托单位:
International Consortium on Fish Toxicogenomics
  • 批准号:
    NE/D000793/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $18.85万
  • 财政年份:
    2006
  • 负责人:
    J Chipman
  • 依托单位:
国内基金
海外基金
果蝇转座元件和piRNA之间的基因组冲突及对杂交不育的影响
  • 批准号:
    91431101
  • 项目类别:
    重大研究计划
  • 资助金额:
    120.0万元
  • 批准年份:
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  • 负责人:
    陆剑
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优化基因组策略搜寻中国藏族内耳畸形的致病基因及其致聋机制研究
  • 批准号:
    31071099
  • 项目类别:
    面上项目
  • 资助金额:
    40.0万元
  • 批准年份:
    2010
  • 负责人:
    戴朴
  • 依托单位:
电离辐射诱发间充质干细胞基因组非稳定性的研究
  • 批准号:
    31070759
  • 项目类别:
    面上项目
  • 资助金额:
    34.0万元
  • 批准年份:
    2010
  • 负责人:
    白鸥
  • 依托单位:
辣椒胞质雄性不育恢复性主效基因精密图谱分析