Training New Investigators in Neuroimaging and in the Neuropsychiatry of Movement

描述（由申请人提供）：这项以患者为导向的研究（K24）职业中期研究者奖申请计划允许PI将50%的精力投入到所述的指导和研究活动中。PI是一位经过委员会认证的神经精神病学家，在精神病学住院医师之后完成了为期两年的运动障碍和神经影像学研究。他贡献了新的神经影像学方法，并将其应用于帕金森病和TS的神经精神方面。他目前的研究包括这两个领域的研究，但这个应用程序的重点是PI对抽动秽语综合征（TS）的研究。这包括由NIMH和Tourette综合征协会资助的正在进行的神经成像研究，以及针对该应用提出的新TS成像研究。这些新研究以PI过去的研究为基础，跟进最近发表的TS研究中令人兴奋的线索，并计划与儿童神经病学和儿童精神病学的同事合作，进一步开发一个关于TS的协调研究计划。多年来，PI已经指导了40多名年轻的学员，其中许多人在夏季或学期短暂停留，但有些人的任期较长。在过去的3年中，PI的长期临床实习生（精神病学住院医师和临床神经心理学家博士后）中有2人因其实验室的研究和整体职业潜力而获得了美国神经精神病学协会的青年研究者奖。PI现已确定新的医学博士。研究员和学生，他们的培训将通过额外的时间来加强，以开展本文建议的具体导师活动。该机构是众所周知的神经科学研究的一个充满活力的中心，其最近获得的CTSA赠款部分将进一步支持本提案中的培训和研究活动。该部门承诺将PI从医学院核心精神病学见习的行政职责以及住院或咨询联络临床职责中解放出来，以换取该K24奖项将支持的指导和以患者为导向的研究机会。简而言之，申请人的指导经验，研究贡献和近期的TS研究计划都达到了K24适当支持的完美时刻。 公共卫生相关性：PI是一位经过委员会认证的神经精神病学家，在精神病学住院医师之后完成了为期两年的运动障碍和神经影像学研究。本申请侧重于PI对Tourette综合征（TS）的研究，包括由NIMH和Tourette综合征协会资助的正在进行的研究以及为此申请提出的新研究。该K24奖项将使PI能够投入更多的时间来指导更多的新研究人员进行以患者为导向的研究，特别是Tourette综合征（TS）的临床和神经影像学研究。

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient-Oriented Research (K24) is planned to allow the PI to devote 50% effort to the mentoring and research activities described. The PI is a board-certified neuropsychiatrist who completed a two-year movement disorders and neuroimaging fellowship after psychiatry residency. He has contributed new neuroimaging methods and applied them to neuropsychiatric aspects of Parkinson disease and TS. His current research includes studies in both these areas, but this application focuses on the PI's research into Tourette syndrome (TS). This includes ongoing neuroimaging studies funded by NIMH and the Tourette Syndrome Association, and new TS imaging studies are proposed for this application. The new studies build on the PI's past research, follow up on exciting leads from recently published TS research, and are planned to further develop a coordinated research program on TS in collaboration with colleagues from child neurology and child psychiatry. The PI has mentored over 40 young trainees over the years, many of them for brief summer or semester stints, but some for longer terms. In the past 3 years, 2 of the PI's longer-term clinical trainees (a psychiatry resident and a clinical neuropsychologist post-doc) have won the American Neuropsychiatric Association's Young Investigator Award for research done in his lab and for their overall career potential. The PI has now identified new M.D. research fellows and students whose training will be enhanced by additional time for the specific mentorship activities proposed herein. The institution is well known as a vibrant center for neuroscience research, and its recently awarded CTSA grant components will further support the training and research activities in this proposal. The department has committed to free the PI from his administrative duties with the medical school core psychiatry clerkship and from inpatient or consultation-liaison clinical duties in exchange for the mentorship and patient-oriented research opportunities that this K24 award will support. In short, the applicant's mentoring experience, research contributions, and near-future plans for research on TS have all arrived at the perfect moment for appropriate support from the K24. PUBLIC HEALTH RELEVANCE: The PI is a board-certified neuropsychiatrist who completed a two-year movement disorders and neuroimaging fellowship after psychiatry residency. This application focuses on the PI's research into Tourette syndrome (TS), including ongoing studies funded by NIMH and the Tourette Syndrome Association and new studies proposed for this application. This K24 award will allow the PI to devote substantially more time to mentoring additional new investigators in patient-oriented research, specifically clinical and neuroimaging investigations of Tourette syndrome (TS).