Integrated Training in Pharmacological Sciences

描述（由申请人提供）：西奈山药理科学综合培训计划旨在提供严格的跨学科博士前培训，以控制生理和病理生理过程和药物作用的基本机制。该计划的目标是提供教育活动和研究培训，将基本机制发现与治疗方式联系起来，包括药物靶点的识别和先导治疗化合物的开发。该培训计划旨在实现深入的培训，再加上广阔的视野，使学员能够在整个职业生涯中融入新兴的新领域。该计划还旨在创造一个学习环境，促进独立思考和个人分析能力，同时培养在协作学习和研究环境中工作的能力。该计划结合了药理学和系统生物学的综合教学培训的核心，在生理学和疾病病理生理学的背景下提供生物化学，结构生物学，遗传学，细胞和分子生物学的核心原则的基础。计算和建模方法系统的问题，在不同的尺度，大型数据集和流行病学的问题，介绍了整个，连同支持，使学生具有不同的进入水平的定量技能取得成功。该课程在基础和高级课程中采用综合主动学习方法，并通过具体的教学创新得到加强。它们包括异步讨论以及课堂讨论和使用同行评价方法，为学生未来职业生涯的这一主要特征做好准备。该培训计划的49名参与教师来自13个学术部门和研究所，其中包括临床和基础科学重点的混合。他们的研究项目为项目学员提供了解决生物医学不同领域重要问题的机会，这些领域具有强大的药理学和/或系统生物学界面和翻译潜力。跨学科和翻译培训环境和计划的结构促进了我们的学员进入独立的科学事业。相关性（参见说明）：产生改善不同人类疾病的新药的突破性进展，产生新的诊断或新的治疗策略，越来越依赖于将定量计算方法应用于疾病和药物相互作用的复杂生物学的研究人员。我们的目标是培养有才华的博士和MD/博士生的这些技能，使他们能够实现下一代的突破。

DESCRIPTION (provided by applicant): The Integrated Training in Pharmacological Sciences program at Mount Sinai aims to provide rigorous interdisciplinary pre-doctoral training in the fundamental mechanisms that control physiological and pathophysiological processes and drug action. It is the goal of this program to provide educational activities and research training that connect the basic mechanistic findings to therapeutic modalities including the identification of drug targets and development of lead therapeutic compounds. The training program seeks to achieve in-depth training coupled with a broad perspective that equips the trainees to incorporate emerging new areas throughout their careers. The program also seeks to create a learning environment that promotes independent thinking and individual analytical skills, while fostering the ability to work in collaborative learning and research environments. The program combines a core of integrated didactic training in Pharmacology and Systems Biology that provides grounding in core principles of biochemistry, structural biology, genetics, cellular and molecular biology within a context of physiology and disease pathophysiology. Computational and modeling approaches to systems problems at various scales, to large data sets and to epidemiological problems are introduced throughout, together with support that enables students with different entering levels of quantitative skills to succeed. This curriculum uses an integrated active learning approach in both basic and advanced courses that is enhanced by specific pedagogical innovations. They include asynchronous discussions as well as in-class discussions and use of peer evaluation methodologies that prepare students for this major feature of their future careers. The 49 participating faculty of this training program are drawn from 13 academic departments and institutes that include a mix of clinical and basic science emphases. Their research projects provide opportunities for program trainees to tackle important problems in diverse areas of biomedicine that have strong pharmacological and/or systems biology interfaces and translational potential. The interdisciplinary and translational training environment and the structure of the program foster the entry of our trainees into independent scientific careers. RELEVANCE (See instructions): Breakthroughs that yield new drugs that ameliorate different human diseases, that yield new diagnostics or new therapeutic strategies depend more and more upon researchers who apply quantitative computational methods to the complex biology of disease and drug interactions. We aim to foster these skills in talented PhD and MD/PhD students, enabling them to achieve the next generation of breakthroughs.