Cellular and molecular foundations of biomedical science

描述(由申请者提供)：这份培训拨款提案的标题是“生物医学科学的细胞和分子基础”。这是六年前启动的一个成功项目的更新，该项目旨在培训研究生生物医学的广泛基础知识，为他们提供理解现代生物学和健康中的重要问题的工具。这是通过两个学期的核心课程完成的，涵盖遗传学、基因组学和生物信息学、真核生物分子生物学、分子生物物理学、蛋白质结构和功能以及细胞生物学。学生在此基础上选修他们感兴趣的特定领域的课程。这个跨部门的项目以生物科学系为基础，但已经扩大到包括哥伦比亚内科和外科学院的现有教员。学生们在最多三个实验室轮流工作，并可以在该项目的47名教职员工中的任何一家完成论文工作，其中大约一半在医学院校园。这为优秀实验室的学生提供了更多的培训机会，并促进了哥伦比亚大学医学院和主校区师生之间的合作。这些教师在广泛的领域工作，包括结构生物学、分子生物学、遗传学、生物信息学和系统生物学、发育生物学和神经生物学。实验系统也很广泛，包括细菌、酵母、果蝇、线虫、青蛙和老鼠。人体组织培养系统也被利用，大多数系统考虑与人类健康和生理相关的问题。每年需要12个研究生实习生职位来支持6名学生，每个为期两年，通常是在他们的第三和第四年。这将为我们目前63名符合培训资助资格的学生池中的19%提供资金。我们项目中最优秀的学生将由这笔助学金资助。这将取决于他们在核心课程和其他课程中的表现，他们的轮换和论文赞助商的建议，以及由基金指导委员会审查的简短研究提案。哥伦比亚大学的师资和研究设施非常优秀，为学生提供了一流的培训环境。相关性：对下一代生物医学科学家的培训对于美国研究的持续卓越以及在理解、控制和治疗人类疾病方面的进步至关重要。该计划中的实验室解决生物医学科学中的特定基本问题，其中许多与人类疾病直接相关。

DESCRIPTION (provided by applicant): This training grant proposal is entitled "The cellular and molecular foundations of biomedical sciences". It is a renewal of a successful program started six years ago and seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through a two semester Core course covering Genetics, Genomics and Bioinformatics, Eukaryotic molecular biology, Molecular biophysics, Protein structure and function, and Cell biology. Students follow this with electives in specific fields of their interest. This interdepartmental program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons. Students undertake rotations in up to three laboratories and can do their thesis work in any of the 47 faculty in the program, roughly half of which are on the Medical School campus. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty members work in a broad range of fields including structural biology, molecular biology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Twelve graduate student traineeships are requested per year to support six students for two years each, usually in their third and fourth years. This will fund 19% of our current training grant eligible student pool of 63. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provides a superb training environment for the students. RELEVANCE: The training of the next generation of biomedical scientists is essential to continued excellence of research in the U.S. and advances in understanding, controlling and curing human disease. Laboratories in the program address specific basic problems in biomedical sciences, many with direct applications to human disease.