Study of Women's Health Across the Nation - Coordinating Center

描述（由申请人提供）：全国妇女健康研究（SWAN）是一项7中心多种族纵向研究，旨在描述绝经过渡期间发生的生理和心理社会变化。SWAN积累了十年来有关转型期内分泌学以及与中年健康和衰老相关的其他因素的数据。由于SWAN要求第四次更新，该研究本身建议从更年期研究过渡到女性衰老研究。SWAN IV项目开始时参与者的平均年龄为59岁（54至65岁），SWAN IV将跟踪这些妇女的59至70岁。SWAN具有前所未有的能力，可以将其在中年和更年期过渡期间收集的广泛的生物，医学，社会，行为和人口统计数据与老年早期积极和不利的健康状态的发展联系起来。SWAN IV的主要目的是：1）描述绝经后妇女的内分泌学和生殖学特征（末次月经后2至12年）; 2）确定额外的健康结果（如测量的身体表现），这是相关的早期老年范围，并可能受到影响的因素，我们已经研究了在中年和3）了解之间的关系，妇女的生活和更年期过渡经历以及随后的积极和消极健康结果。为了实现这一目标，研究人员建议每年进行电话联系，以密切跟踪绝经状态，绝经症状和选定的健康事件。此外，还建议进行两次面对面的诊所访问，以完成对早期疾病的详细身体测量。SWAN IV的主要专题领域包括1）身体功能; 2）骨骼/骨质疏松症; 3）认知功能/症状/心理健康和4）心血管。SWAN的新领域包括身体表现和骨关节炎、重度抑郁症史和颈动脉壁厚度。SWAN将继续监测症状、认知、心血管危险因素、内分泌、骨密度和骨折。SWAN IV将促进我们对与更年期过渡相关的可改变的风险因素如何与亚临床疾病措施和硬结果相关联的理解。这可能导致改进妇女疾病初级预防战略。 相关性：SWAN汇编了迄今为止以社区为基础的样本中妇女从绝经前到绝经后的健康和生理及心理社会变化的最全面的特征。特别重要的是，SWAN的继续将使研究能够增加对这些更年期相关变化对随后的健康和年龄相关疾病风险因素的影响的理解。

DESCRIPTION (provided by applicant): The Study of Women's Health Across the Nation (SWAN) is a 7-center multi-ethnic longitudinal study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. SWAN has amassed ten years of data about endocrinology of the transition and other factors relevant to midlife health and aging. As SWAN requests its fourth competing renewal, the study itself proposes to transition from a study of the menopause to a study of aging in women. The average age of participants at the beginning of the SWAN IV project will be 59 years (54 to 65) and SWAN IV will follow these women through the age range of 59 to 70. SWAN has the unprecedented capability to link the expansive biological, medical, social, behavioral, and demographic data it has collected during mid-life and the menopausal transition to the development of both positive and adverse health states in early oldage. The primary objectives of SWAN IV are to: 1) Characterize the endocrinology and symptomotology of the post-menopause (2 to 12 years after final menses); 2) Ascertain additional health outcomes (such as measured physical performance) that are relevant to the early old age range and that may be affected by the factors that we have studied in mid-life and 3) Understand the relations between the mid-life and menopausal transition experience of women and subsequent positive and negative health outcomes. To accomplish this, the investigators propose annual phone contact to closely track menopausal status, menopausal symptoms and selected health events. In addition, two in-person clinic visits are proposed to accomplish detailed physical measures of early disease. The major thematic areas of SWAN IV include 1) Physical Functioning; 2) Bone/Osteoporosis; 3) Cognitive Function/ Symptoms/ Mental Health and 4) Cardiovascular. New areas for SWAN include physical performance and osteoarthritis, history of major depression, and carotid wall thickness. SWAN will continue to monitor symptoms, cognition, cardiovascular risk factors, endocrinology, bone density and fractures. SWAN IV will advance our understanding of how modifiable risk factors related to the menopause transition are linked to sub-clinical disease measures and hard outcomes. This may lead to improved strategies for the primary prevention of disease in women. RELEVANCE: SWAN has compiled the most comprehensive characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples. Of particular public health importance is that the continuation of SWAN will permit the study to increase understanding of the effects of these menopause-related changes on subsequent health and risk factors for age-related diseases.