Identifying novel pathways of red blood cell differentiation by CRISPR screening

红细胞为所有器官提供氧气，对所有脊椎动物的健康都是必不可少的。因此，影响红细胞的疾病可能会给患者带来毁灭性的后果。在某些疾病中，造血祖细胞不能完全成熟为红血球，导致红血球短缺。因此，我的目的是更好地了解红细胞成熟的分子过程，以发现治疗红细胞疾病的新靶点。

Red blood cells supply all organs with oxygen and are essential to the health of all vertebrate organisms. Thus, disorders affecting red blood cells can have devastating outcomes for patients. In some diseases, blood progenitor cells fail to fully mature into red blood cells which results in a shortage of red blood cells. Hence, my aim is to better understand the molecular processes of red blood cell maturation to discover novel therapeutic targets for red blood cell disorders.