GENIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近的大规模遗传流行病学研究已经确定了新定义的2型糖尿病易感基因。然而，这些假定的疾病易感基因座易患糖尿病的病理生物学机制仍有待进一步确定。这项研究的目的是确定遗传标记，如锌转运蛋白SLC30A8或转录因子7-样2(TCF7L2)基因中的DNA变体，是否可以用于识别高危非裔美国人(AA)中易患β细胞功能受损和最终发展为糖尿病的个体。其具体目标是：1)建立超重/肥胖、非糖尿病的非洲裔美国人的良好表型样本，在GCRC环境中仔细描述葡萄糖/胰岛素代谢；2)确定SLC308A8和TCF7L2基因变异是否与超重/肥胖的非裔美国人的胰岛素分泌障碍有关。这些研究最终应该为基于遗传标记的“预测性健康”模型奠定基础，这将使临床医生能够更有效地识别高危糖尿病前期患者，并有针对性地进行预防干预。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent large-scale genetic epidemiology studies have identified newly defined susceptibility genes for Type 2 Diabetes. However, the pathobiological mechanisms by which these putative disease susceptibility loci predispose to diabetes remains to be further defined. The goal of the study is to determine whether genetic markers such as DNA variants in the zinc transporter SLC30A8 or the transcription factor 7-like 2 (TCF7L2) genes can be used to identify individuals with increased susceptibility to impaired beta-cell function and the eventual development of diabetes within an at risk African American population (AA). The specific aims are: 1) Establish a well-phenotyped sample of overweight/obese, non-diabetic African-American subjects that undergo careful characterization of glucose/insulin metabolism in the GCRC setting and 2) Determine if variants in SLC308A8 and TCF7L2 genes are associated with impaired insulin secretion in overweight/obese African Americans. These studies should eventually lay the groundwork for 'Predictive Health' models based on genetic markers that will enable clinicians to more effectively identify high-risk pre-diabetic patients and target preventive interventions.