课题基金 / 基金详情

项目摘要

项目成果

Emma Heart的其他基金

相似基金

相关文献

中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Through previous collaborations with scientists at the Biocurrents Research Center, we demonstrated the role of pH in mediating the toxicity of alloxan in pancreatic beta islets. Self-referencing oxygen sensing electrodes have proven to be an ideal way to study isolated islet function (oxygen consumption) in real time. It is well recognized that oxygen consumption by islets is strongly correlated with insulin release. Alloxan stability and thus toxicity is affected by pH. We have established that presence of glucose dampens alloxan toxicity in pancreatic islets. This effect is due to the intracellular alkalinization, caused by glucose metabolism. We propose to expand this collaboration by studying the role of oxidative stress in beta islet function. Previous studies have demonstrated that oxidative stress can positively and negatively impact beta islet function. While streptozotocin-induced islet toxicity can be blocked by catalase and superoxide dismutase expression, hydrogen peroxide also seems to play an important role in signaling in response to glucose stimulation. The mechanisms by which islets differentiate between harmful and helpful oxidative stress are not clear.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cytosolic and Plasma Membrane Circuitry of Beta Cell Redox Control: Role in Survival, Oxidative Defense and Insulin Secretion
  • 批准号:
    9122398
  • 项目类别:
  • 资助金额:
    $32.52万
  • 财政年份:
    2015
  • 负责人:
    Emma Heart
  • 依托单位:
Cytosolic and Plasma Membrane Circuitry of Beta Cell Redox Control: Role in Survival, Oxidative Defense and Insulin Secretion
  • 批准号:
    9017546
  • 项目类别:
  • 资助金额:
    $17.56万
  • 财政年份:
    2015
  • 负责人:
    Emma Heart
  • 依托单位:
Cytosolic and plasma membrane circuitry of beta cell redox control
  • 批准号:
    8580092
  • 项目类别:
  • 资助金额:
    $34.91万
  • 财政年份:
    2013
  • 负责人:
    Emma Heart
  • 依托单位:
Cytosolic and Plasma Membrane Circuitry of Beta Cell Redox Control
  • 批准号:
    8729578
  • 项目类别:
  • 资助金额:
    $13.11万
  • 财政年份:
    2013
  • 负责人:
    Emma Heart
  • 依托单位:
海外基金