Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases

项目A 主要研究者： 伊曼纽尔·米尼奥 职务名称： 研究管理核心，人类DNA样本库，动物模型和数据库 描述（由申请人提供）：一个经验丰富，训练有素的研究管理人员是一个复杂的多学科计划项目的有效管理至关重要。在过去连续18年的资助该计划项目的主要研究者和睡眠研究中心的助理主任一起工作，并建立了一个研究管理员和研究支持人员团队，负责管理嗜睡症中心的日常活动。这包括预算和财务报告规划，监督政策和指导方针，动物和人类数据库管理，受试者招募以及将该项目整合到睡眠研究中心和睡眠诊所，并确保该项目顺利运行。为了支持这一修订后的研究提案，确认了五项主要核心活动：1）研究管理和协调职能，以促进研究者和项目之间的研究和互动2）管理本提案中使用的斯坦福大学嗜睡症动物群中心;这包括斑马鱼、小鼠和大鼠。3)招募人类发作性睡病患者用于研究项目：这包括来自发作性睡病和对照受试者的DNA、血清、脑脊液和大脑样本库。4)维护计算机化数据库，其中包括人类、小鼠/大鼠、犬嗜睡症数据和组织样本数据;维护项目网站和在线数据共享。5)维护所有支持遵守所有联邦指导方针和政策进行研究的文件。主要研究者有责任确保嗜睡症中心的科学家作为一个综合团队开展工作。他的方向和科学的领导，是必不可少的追求的总体目标的计划。每周举行一次研究会议，以促进研究者之间以及研究人员和研究管理人员之间的沟通。

PROJECT A PI: Emmanuel Mignot Title: Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases Description (provided by applicant): A seasoned and well-trained research administration staff is essential for the effective management of a complex multi-disciplinary program project. During the last consecutive 18 years of funding of this program project the Principal Investigator and the Assistant Director of the Sleep Research Center have worked together and built a team of research administrators and research support staff that are responsible for the day-to-day activities of managing the Center for Narcolepsy. This includes budgetary and fiscal reporting planning, oversight of policy and guidelines, animal and human database management, subject recruitment and the integration of this project into the Sleep Research Center and Sleep Clinic, and in general ensuring that the program runs smoothly. To support this revised research proposal, five main core activities are recognized: 1) A research administrative and coordinating function to facilitate the research & interactions among investigators and projects 2) Management of the Stanford University Center for Narcolepsy animal colonies used in this proposal; this includes zebrafish, mice, and rats. 3) Recruitment of human narcolepsy patients for research projects: this includes the banking of DNA, serum, cerebrospinal fluid and brain specimens from narcolepsy and control subjects. 4) Maintenance of computerized databases containing human, mouse/rat, canine narcolepsy data and tissue sample data; maintenance of the project's website and data-sharing on-line. 5) Maintenance of all documentation supporting adherence to all federal guidelines and policies for conducting research. It is the responsibility of the Principal Investigator to assure that the Center for Narcolepsy scientists work as an integrated team. His direction and scientific leadership, is essential to the pursuit of the overall goals of the program. A weekly research meeting is held to facilitate communication among the investigators and between the research staff and research administration staff.