The Center for Translational Genomic Phenotyping

描述（由申请方提供）：加州大学（UC）戴维斯翻译基因组表型分析中心（CTGP）：美国国家癌症研究所-人类癌症小鼠模型联盟（NCI-MMHCC）科学领导应用将提供集中发现驱动的体内和离体表型分析，用于模型病理学验证。这主要集中在癌症生物学，但也影响预防性干预，实验治疗和癌症易感性计划。该应用程序分为五个部分。1.作为研究总结，主要研究者Robert卡迪夫博士是过去和新提交的几个MMHCC研究项目的共同研究者、共同研究者和合作者。他是与刘易斯Chodosh，科里Abate-Shen和罗伯特Schreiber提交的“目标1”研究申请的共同作者。他一直在MMHCC联盟内提供咨询和领导，涉及表型，小鼠病理学结果向人类疾病的转化，以及定义和宣传诊断，分期和分级标准，这些标准对在癌症生物学，预防和实验治疗中使用小鼠模型至关重要。2.领导计划将：A）以电子方式协调预防性干预和癌症生物学特定研究集群中的NCI-MMHCC内部项目，并预期促进与这些研究集群有关联的U 01获奖者之间的合作; B）促进MMHCC以及与其他NCI网络和联盟的合作，以确定促进集群合作的研究资源或试点项目;以及C）通过具有体内和离体图像的集成图像档案的caELMIR管理和增强现有的NCI癌症模型生物信息学基础设施，所述图像档案被准确地映射到协作的相关人类生物信息学系统。3.沟通和协调将通过连接MMHCC研究分支机构与基因组病理学研究院所包含的专家病理学/表型资源的信息学工具来实现。该小组由该国最主要的权威机构和最有经验的小鼠模型和比较病理学家组成。4.外联将通过研讨会和讲习班，以及在加州大学戴维斯分校中心开放的访问实习生/访问教授计划实现。此外，加州大学戴维斯分校与突变小鼠区域资源中心和敲除小鼠项目库的联系为小鼠建模社区提供了额外的服务。5. MMHCC和NCI的临床前模型信息学部分由我们在加州大学戴维斯分校的团队开发。研究已经在加州大学戴维斯分校启动，具体的试点项目设计要求使用caELMIR、caMOD和caBIG基础设施从小鼠集落管理、病理学实验室信息系统、全切片图像、放射学图像数据和显示器以及电子“实验室笔记本”中获得准确的集成数据。此应用程序与程序优先级唯一相关。这是一个以表型和病理学为中心的领导U 01，得到了许多国家小鼠病理学专家的广泛支持，以及为MMHCC联盟的目的而专门设计的信息学开发方面的广泛背景和初步工作。

DESCRIPTION (provided by applicant): The University of California (UC), Davis Center for Translational Genomic Phenotyping (CTGP): A National Cancer Institute-Mouse Models of Human Cancer Consortium (NCI-MMHCC) Science Leadership Application will provide centralized discovery-driven in-vivo and ex-vivo phenotyping for validation of model pathology. This is predominantly centered on Cancer Biology, but Impacts Preventative Interventions, Experimental Therapeutics and Cancer Susceptibility programs as well. The application is organized in five sections. 1. As a Summary of the Research, the PI, Dr. Robert Cardiff, is a Co-Pl, Co-I and collaborator on several past and newly submitted MMHCC research projects. He Is Co-l on "Goal 1" research applications submitted with Lewis Chodosh, Cory Abate-Shen, and Robert Schreiber. He has consistently provided consultation and leadership within the MMHCC Consortium with respect to phenotypes, translation of pathologic findings in the mouse to the human disease, and defining and publicizing criteria for diagnosis, staging and grading critical to the use of the mouse models in cancer biology, prevention, and experimental therapeutics. 2. The Leadership Plan will A) electronically coordinate intra-NCI-MMHCC projects in the specific research clusters of Preventative Interventions and Cancer Biology and anticipate fostering collaborations among the U0l awardees who are affiliated with these research clusters; B) foster collaborations throughout the MMHCC and with other NCI networks and consortia to delineate research resources or pilot projects that promote the cluster collaborations; and C) manage and enhance the existing NCI cancer model bioinformatics infrastructure through caELMIR with Integrated image archives of in-vivo and ex-vivo images that are accurately mapped to relevant human bioinformatics systems in collaboration. 3. The Communication and Coordination will be achieved through the informatics tools connecting the MMHCC research affiliates with the expert pathology/phenotyping resource embodied In the Academy for Genomic Pathology. This group constitutes most of the leading authorities and most experienced mouse model and comparative pathologists in the country. 4. Outreach will be achieved through symposia and workshops, as well as an open visiting trainee/ visiting professor program at the UC Davis center. In addition, the connections at UC Davis to the Mutant Mouse Regional Resource Center, and the Knockout Mouse Project Repository provide added outreach to the mouse modeling community. 5. Pre-Clinical Models Informatics for the MMHCC and the NCI has been developed, in part, by our group at UC Davis. Studies have been Initiated at UC Davis, and specific pilot projects designs demanding accurate integrated data from mouse colony management, pathology laboratory information systems, whole slide images, radiology image data and display and electronic "lab notebooks" using caELMIR, caMOD, and the caBIG infrastructure. This application is uniquely relevant to the program priorities. This is a Leadership U01 centered on phenotyping and pathology, with extensive support from a host of national experts In mouse pathology, and extensive background and preliminary work In development of Informatics uniquely designed to the purposes of the MMHCC consortium