Identifying regulators of the DNA damage response and tumourigenesis using C. elegans

到85岁时，澳大利亚每两个男人中就有一个会患上癌症，每三个女人中就有一个会患上癌症。遗憾的是，并不是所有的癌症都对目前的治疗有效。最近，一种防止某些癌症对化疗产生反应的新机制被发现，它涉及一种名为HIPK的蛋白质。我们正在使用一个简单的模型系统，线虫秀丽线虫，以发现可以克服这一阻碍癌症治疗成功的方法，以期开发新的治疗药物。

By the age of 85, one in two men and one in three women in Australia will develop cancer. Regrettably, not all cancers respond to current therapies. Recently a new mechanism that prevents certain cancers from responding to chemotherapy has been identified, involving a protein called HIPK. We are using a simple model system, the nematode Caenorhabditis elegans, to discover ways in which this block to successful cancer treatment can be overcome, with the view to developing new therapeutic agents.