Protective and pathogenic B cell epitopes in Francisella tularensis

B细胞表位发现和抗体产生机制项目的目标是鉴定新的B细胞表位，阐明抗体介导的保护或发病机制的新机制，这些机制在人类对新出现和再出现的传染病和潜在的生物恐怖主义病原体及其毒素的体液免疫中很重要。这项B细胞表位发现计划的结果将促进我们对抗体功能的理解，并极大地促进改进免疫治疗、诊断和疫苗的设计和开发。此外，已知B细胞表位和抗体功能列表的扩展将有助于开发更强大的算法和数学模型，以预测B细胞表位和抗体介导的体内病原体和毒素的免疫反应。该合同将鉴定土拉菌弗朗西斯菌的表位

The goal of the B Cell Epitope Discovery and Mechanisms of Antibody Production program is to identify novel B cell epitopes and elucidate novel mechanisms of antibody-mediated protection or pathogenesis that are important in humoral immunity in humans to emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. Results from this B cell epitope discovery program will advance our understanding of antibody functions and greatly facilitate the design and development of improved immunotherapeutics, diagnostics, and vaccines. In addition, an expansion of the list of known B cell epitopes and antibody functions will facilitate the development of more robust algorithms and mathematical models to predict B cell epitopes and antibody-mediated immune responses to pathogens and toxins in vivo. This contract will identify epitope from Francisella tularensis bacterium