The Forsyth Core Center for Discovery at the Host-Biofilm Interface

描述(由申请人提供)：福赛斯学院的第二个世纪将在地理位置、研究机会和资源可获得性方面看到令人兴奋的新变化。2010年，口腔和颅面研究领域的世界领先者Forsyth将迁往马萨诸塞州剑桥。新地点的未分配生长空间将用于在宿主-生物膜界面(CHBI)建立新的发现中心。CHBI将利用现有的Forsyth科学家团队，通过将他们的专业知识集中在宿主和生物膜的联系上，来探索免疫和微生物的特征和相互作用。CHBI还将为根据P30机制招聘2名新培训的教师提供基础，他们将为探索宿主-生物膜界面带来新的专业知识、视角和技术技能。我们将集中招募在1)上皮-微生物相互作用；2)微生物定植个体发育，使用无菌小鼠模型；3)共生关系的建立和维持；以及4)先天性和获得性免疫反应之间的相互作用方面接受培训的个人。新的CHBI教员将获得终身教职跟踪助理工作人员的任命，基本上将拥有100%受保护的研究时间，并将获得启动资金(调查员和技术员、用品、设备、旅行和其他研究需要的五年工资)。P30支持的试点助学金将专注于合作和多学科的CHBI项目，涉及和/或由新的CHBI教师领导。将通过高级工作人员和CHBI指导委员会的指导、参加研讨会以及通过哈佛CTSC催化剂网络促进机构间合作，包括Catalyst的试点赠款计划，大力强调新的调查员职业发展。认识到在职业生涯的早期阶段需要持续的支持，Forsyth将提供额外3年的工资和技术支持。福赛斯还将承担行政支持、招聘和空间翻新的费用。我们的目标是扩大CHBI的科学覆盖范围和影响，通过在宿主-生物膜界面进行重点调查，部分通过包括新教师的观点，以及通过创造一个环境，使他们成熟为完全独立的研究生涯。 与公共卫生相关：人类体内的细菌数量是体内细胞数量的10倍。我们与这些微生物中的大多数和谐相处；然而，其中一些细菌可能会变得致病。这项工作的目标是招募和发展两名新的研究人员的职业生涯，从新的角度探索人类和我们的细菌乘客通常是如何共存的，以及当疾病发生时会发生什么变化。

DESCRIPTION (provided by applicant): The Forsyth Institute's second century will see exciting new changes in location, research opportunities and resource availability. In 2010, Forsyth, the world leader in oral and craniofacial research will relocate to Cambridge, MA. The uncommitted growth space at the new site is being targeted for a new Center for Discovery at the Host-Biofilm Interface (CHBI). The CHBI will take advantage of existing teams of Forsyth scientists already exploring immune and microbial characteristics and interactions by focusing their expertise at the nexus of host and biofilm. The CHBI will also provide the base for recruiting 2 newly trained faculty, under the P30 mechanism, who will bring new expertise, perspectives, and technical skills to the exploration of the host-biofilm interface. We will concentrate our recruitment on individuals trained in emerging themes of 1) epithelial-microbial interactions; 2) ontogeny of microbial colonization, using germfree mouse models; 3) establishment and maintenance of commensalism; and 4) cross-talk between innate and adaptive immune responses. New CHBI faculty will be given tenure-track Assistant Member of Staff appointments, will have essentially 100% protected research time, and will be provided with start-up funds (five total years of salary for investigator and technician, supplies, equipment, travel and other research needs). P30-supported pilot grants will focus on collaborative and multi-disciplinary CHBI projects involving and/or led by new CHBI faculty. A strong emphasis will be placed on new investigator career development through mentoring by senior staff and the CHBI Steering Committee, participation in workshops, and by promoting interinstitutional collaborations through the Harvard CTSC Catalyst network, including Catalyst's pilot grant program. Recognizing the need for sustained support during the early career phase, Forsyth will provide salary and technical support for an additional 3 years. Forsyth will also underwrite costs for administrative support, recruitment, and space renovation. Our goals are to expand the scientific reach and impact of the CHBI by focused investigation at the host-biofilm interface, in part, by including the perspectives of new faculty, as well as by creating an environment for their maturation into fully independent research careers. PUBLIC HEALTH RELEVANCE: Humans are colonized by 10 times more bacteria than there are cells in our bodies. We live in harmony with most of these microbes; however, some of these bacteria may become pathogenic. The goal of this effort is to recruit and develop the careers of two new investigators to explore from new perspectives how humans and our bacterial passengers normally coexist and what changes when disease occurs.