Alcohol Sensitivity and PET Derived Measures of Opioid Activity

酒精是美国最常见的滥用药物之一，有10%的人 在他们生命中的某个阶段，受酒精依赖影响的人群。研究 在过去的20年里，已经证明了主观上的个体差异 对酒精的反应可能会影响一个人的饮酒模式，是一种强烈的 未来酗酒问题的预测者。对酒精反应低的人有 酒精中毒的风险增加，当对酒精有高反应的人 降低了酗酒的风险。MU二倍体受体参与调控 与健康对照组相比，最近戒酒的人饮酒行为的发生率更高。目前的应用程序进一步调查 脑内MU阿片受体的差异与脑损伤的关系 个体对酒精的主观反应存在差异。我们将招募健康的 将完成酒精挑战程序并进行表型鉴定的社交饮酒者 根据他们对酒精的反应水平。受试者表现出很高的反应和 对酒精反应低的患者将接受[C11]卡芬太尼PET扫描以获得更多 以确定MOR BP的个体差异是否与酒精敏感性有关 在受控的实验室条件下。拟议的研究结果将 增加我们对个体变异性之间关系的理解 阿片系统和对酒精的主观敏感性。

Alcohol is one olthe most commonly abused drugs in the US, with 10% of the population affected by alcohol dependence at some point in their lives. Research over the last 20 years has demonstrated that individual dIfferences in subjective responses to alcohol may influence a person's pattern of alcohol use and is a strong predictor of future alcoholproblerns. Individuals with a low response to alcohol have an Increased-risk for alcoholism, where as Individuals With a-high response to alcohol have a reduced risk for alcoholism. Mu oploid receptors are involved in modulation of drinking behaviors and have been shown to be higher in recently abstinent alcoholics when compared to healthy controls. The current application furthur investigates the relationships between differences In brain mu opioid receptors and Individual differences In subjective responses to alcohol. We will recruit healthy social drinkers who Will complete an alcohol challenge procedure and be phenotyped based on their level of response to alcohol. Subjects who show a high response and a low response to aIcohol will undergo a [C11] carfentanil PET scan toobtain MOR BP to determine if individual differences in MOR BP are related to alcohol sensitivity under controlled laboratory conditions. The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol.