Alcohol Sensitivity and PET Derived Measures of Opioid Activity

酒精敏感性和 PET 衍生的阿片类药物活性测量

• 批准号: 7925603
• 负责人: Elise M Weerts
• 金额: $ 67.64万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-05 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7925603
• 关键词: Affect; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Alleles; Amygdaloid structure; Biological; Blood Pressure; Blood alcohol level measurement; Brain; Brain region; Characteristics; Complex; Data; Dependence; Diagnosis; Disease; Dopamine; Enrollment; Etiology; Future; Gene Mutation; General Population; Genetic; Genetic Variation; Genotype; Heart Rate; Heritability; Human; Individual; Individual Differences; Knock-out; Laboratories; Laboratory Animals; Life; Measures; Mediating; Normal Statistical Distribution; Opioid; Opioid Receptor; Opioid Receptor Binding; Oral Administration; Pathway interactions; Patient Self-Report; Pattern; Persons; Phenotype; Physiological; Placebos; Play; Population; Positron-Emission Tomography; Procedures; Psychophysiology; Rat Strains; Receptor Gene; Recruitment Activity; Reporting; Research; Rewards; Risk; Role; Single Nucleotide Polymorphism; Skin Temperature; System; Testing; Variant; Ventral Striatum; alcohol effect; alcohol response; alcohol sensitivity; alcohol use disorder; base; carfentanil; drinking; drinking behavior; drug of abuse; endogenous opioids; endophenotype; genetic association; genetic risk factor; genetic variant; interest; meetings; mu opioid receptors; neurotransmission; preclinical study; problem drinker; receptor; receptor density; response; social

Alcohol is one olthe most commonly abused drugs in the US, with 10% of the population affected by alcohol dependence at some point in their lives. Research over the last 20 years has demonstrated that individual dIfferences in subjective responses to alcohol may influence a person's pattern of alcohol use and is a strong predictor of future alcoholproblerns. Individuals with a low response to alcohol have an Increased-risk for alcoholism, where as Individuals With a-high response to alcohol have a reduced risk for alcoholism. Mu oploid receptors are involved in modulation of drinking behaviors and have been shown to be higher in recently abstinent alcoholics when compared to healthy controls. The current application furthur investigates the relationships between differences In brain mu opioid receptors and Individual differences In subjective responses to alcohol. We will recruit healthy social drinkers who Will complete an alcohol challenge procedure and be phenotyped based on their level of response to alcohol. Subjects who show a high response and a low response to aIcohol will undergo a [C11] carfentanil PET scan toobtain MOR BP to determine if individual differences in MOR BP are related to alcohol sensitivity under controlled laboratory conditions. The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol.

酒精是美国最常滥用的药物之一， 在他们的生活中的某个时候受到酒精依赖影响的人群。研究 在过去的20年里，已经证明了主观上的个体差异 对酒精的反应可能会影响一个人的酒精使用模式， 预测未来的酒精问题。对酒精反应低的人 酒精中毒的风险增加，而对酒精有高度反应的人 降低了酗酒的风险。Mu受体参与调节 与健康对照组相比，最近戒酒的酗酒者的饮酒行为和饮酒行为的关系更高。本申请进一步研究了 大脑μ阿片受体的差异与 对酒精的主观反应的个体差异。我们将招募健康的 将完成酒精挑战程序并进行表型分析的社交饮酒者 根据他们对酒精的反应程度表现出高应答的受试者， 对酒精低反应者将接受[C11]卡芬太尼PET扫描以获得莫尔比 BP，以确定莫尔BP的个体差异是否与酒精敏感性相关 在受控的实验室条件下。拟议研究的结果将 增加我们对个体差异性之间关系的理解， 阿片系统和主观酒精敏感性。