GENETICS CORE

Gl Genetics的核心将在促进以中心为基础的遗传工具的获取方面发挥关键作用 研究项目。基因操作是从生物建模到建立 以及测试正常和临床相关疾病状态下的关键分子信号通路。 基因工具是非常有活力的，每年都有新技术上线。《遗传学》 CORE将成为当前、新兴和未来基因技术的枢纽，提供建议和帮助 中心成员适当地评估并与这些经常具有破坏性的科学进步保持同步。这个 遗传学核心将平衡其在当前(如siRNA、体内成像、微阵列、小鼠胚胎)方面的努力 细胞)，新兴的(例如通过下一代测序和斑马鱼进行的转录组分析 基因敲除)和不久的将来(例如新的DNA输送平台，包括二氧化硅纳米颗粒)遗传学 工具。作为获取遗传技术最新信息的枢纽，这一核心将代表着 通过其培训机会和网站与这一动态研究领域的重要和中心接口 和个人咨询。遗传学核心总监(Stephen C.Ekker，Ph.D.，15%申请时间) 是梅奥诊所的一名新兵，拥有丰富的分子遗传学专业知识。实现…的目标 这项核心，兼职支持生物信息学，生物统计学和遗传学教学的要求。

The Gl Genetics Core will serve a critical role in facilitating access to genetic tools for Center-based research projects. Genetic manipulation is a critical approach from biological modeling to establishing and testing critical molecular signaling pathways in both the normal and clinically relevant disease state. Genetic tools are extremely dynamic, with new technologies coming on line every year. The Genetics Core will serve as a hub for current, emerging and future genetic technologies, advising and helping Center members properly assess and keep abreast of these often disruptive scientific advances. The Genetics Core will balance its efforts on current (such as siRNA, in vivo imaging, microarray, mouse ES cells), emerging (such as transcriptome analyses via next-generation sequencing and zebrafish knockouts) and near-future (such as new DNA delivery platforms including silica nanopartides) genetics tools. As a hub for access to the latest information on genetics technologies, this core will represent an important and central interface to this dynamic research area through its training opportunities, Web site and individual consultation. The Genetics Core Director (Stephen C. Ekker, Ph.D., 15% time requested) is a recent recruit to the Mayo Clinic with extensive molecular genetics expertise. To achieve the goal of this Core, part-time support for bioinformatics, biostatistics and genetics instruction is requested.