EXERCISE IN CHILDREN AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 HCT用于治疗儿童和成人的各种恶性和非恶性疾病。 美国每年进行约6000例HCT，5年以上存活者估计为100，000例。 HCT与几种疾病相关和治疗特异性医学晚期效应相关，这些效应可能限制功能表现，包括瘦体重降低、心肺适应性和血管功能降低以及骨代谢和密度受损。随着时间的推移，这些限制可能会对个人充分参与生活角色的能力产生不利影响，例如参与日常活动或社交互动。我们建议进行一项试点研究，以测试运动干预，计划使用2007年10月提交给美国国立卫生研究院的初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HCT is used to treat a variety of malignant and nonmalignant disorders in children and adults. Approximately 6000 HCTs are performed in the US each year, with the number of 5+ year survivors estimated at 100,000. HCT is associated with several disease-related and treatment-specific medical late effects that have potential to limit functional performance, including decreased lean body mass, reduced cardiopulmonary fitness and vascular functoin, and impaired bone metabolism and density. Over time, these limitations may adversely affect the individual's ability to participate fully in life's roles, such as engaging in daily activities or interacting socially. We propose a pilot study to test an exercise intervention, with plans to use preliminary data for an October 2007 NIH submission.