METABOLIC OUTCOME AFTER ISLET TRANSPLANTATION IN T1DM: A PILOT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该试验项目的总体目标是确定胰岛细胞移植的代谢结果，包括移植后至少9个月的恢复正常血糖、刺激胰岛素分泌、胰岛素脉动性和肝脏胰岛素敏感性。 本研究包括接受同种异体胰岛细胞移植（供体胰岛）治疗1型糖尿病或接受胰腺切除术后自体胰岛细胞移植（自身胰岛细胞）治疗慢性胰腺炎的受试者。 我们将评估这些参数的受试者以前在明尼苏达大学移植作为一个试点项目，作为未来的前瞻性研究的基础上，新的患者移植前后比较免疫抑制方案和结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this pilot project is to determine the metabolic outcome of pancreatic islet cell transplantation with regards to restoration of euglycemia, stimulated insulin secretion, insulin pulsatility, and hepatic insulin sensitivity at least nine months after transplatation. This study includes subjects who received allogenic islet cell transplants (donor islets) for type 1 diabetes or autologous islet cell transplants (their own islet cells) following pancreatectomy for chronic pancreatitis. We will evaluate these parameters in subjects previously transplanted at the University of Minnesota as a pilot project, as a basis for future prospective studies on new patients before and after transplantation to compare immunosuppressive protocols and outcomes.