Type 1 Diabetes-A Proposal for Prevention & Intervention

描述（由申请人提供）：1型糖尿病试验网络联盟于2001年在其前身1型糖尿病预防试验（DPT-1）完成后启动。该网络由14个美国和4个国际临床站点组成。此外，还有200多个美国附属站点进行受试者筛选，一个中央协调中心和几个与试验网络相关的实验室。TrialNet联盟的目标是预防或延迟T1D的发病，测试旨在减少β细胞破坏和/或提高β细胞存活的干预措施，以及对具有残余β细胞功能的T1D患者的机制研究。明尼苏达大学（UMN）从一开始就是DPT-1/TrialNet临床中心。在这段历史中，UMN一直具有很高的生产力和参与度，为项目开发和报告做出了智力贡献，并积极参与每个TrialNet项目的各个方面。这笔续期拨款的目的是在项目开发、筛查、招募、治疗、随访和报告等关键领域，延续UMN作为高质量、高绩效TrialNet临床中心的传统；通过进一步发展和支持UMN附属机构，以及在明尼苏达州博览会的UMN新研究机构内探索一般人群筛查，提高T1D高风险受试者的筛查率；并促进与中西部地区新的T1D研究人员的合作。

DESCRIPTION (provided by applicant): The Type 1 Diabetes TrialNet Consortium was initiated in 2001 following completion of its predecessor, the Diabetes Prevention Trial-Type 1 (DPT-1). This network consists of 14 US and 4 international clinical sites. In addition, there are more than 200 US affiliate sites which perform subject screening, a Central Coordinating Center, and several TrialNet-associated laboratories. The goals of the TrialNet consortium are to prevent or delay the onset of T1D, to test interventions aimed at decreasing beta cell destruction and/or enhancing beta cell survival in persons with T1D with residual beta cell function, and the performance of mechanistic studies. The University of Minnesota (UMN) has been a DPT-1/TrialNet Clinical Center since the beginning. Throughout this history, UMN has been highly productive and engaged, contributing intellectually to project development and reporting, and actively participating in all aspects of each TrialNet project. The aims of this renewal grant are to continue the tradition of UMN as a high-quality, high-performing TrialNet Clinical Center in the critical areas of project development, screening, recruitment, treatment, follow-up, and reporting; to increase screening rates for detection of subjects at high risk for development of T1D by further developing and supporting UMN affiliates and by exploring general population screening within new UMN research facilities at the Minnesota State Fair; and to foster collaborations with new T1D researchers in the Upper Midwest region.