PARTIAL GROWTH HORMONE INSENSITIVITY IN IDIOPATHIC SHORT STATURE/SMALL-FOR-GESTA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目旨在研究特发性身材矮小（ISS）和/或出生小于胎龄（SGA）儿童的部分生长激素不敏感（GHI）。我们建议整合功能，生物化学和分子研究，以确定最可靠的标志物与ISS和/或SGA的儿童有部分GHI，以便把他们对适当的生长激素治疗（更高的生长激素剂量比给予生长激素缺乏症的儿童）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is to investigate partial growth hormone insensitivity (GHI) among children with idiopathic short stature (ISS) and/or born small-for-gestational age (SGA). We propose to integrate functional, biochemical and molecular studies to identify the most reliable markers for children with ISS and/or SGA that have partial GHI in order to put them on appropriate growth hormone treatment (higher growth hormone doses than are given to growth hormone deficient children).