GENOMICS OF KIDNEY TRANSPLANTATION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究提出了一种遗传流行病学方法，使用的数据，部分，收集了一个正在进行的，大型的，前瞻性队列的肾移植受者参加了NIH资助的研究（DeKAF）。这项研究将确定遗传易感性如何有助于解释DeKAF研究中定义的结果。具体来说，这项研究将研究遗传变异（SNP），免疫抑制药代动力学，不良反应和临床结果之间的联系。总体目标是检测药物代谢酶、药物转运蛋白、药物靶点的特定遗传变异与药代动力学、免疫抑制剂不良反应和肾排斥反应相关的生物学途径之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes a genetic epidemiology approach using data, in part, collected by an ongoing, large, prospective cohort of kidney transplant recipients enrolled in a NIH-funded study (DeKAF). This study will determine how genetic predisposition may help to explain the outcomes defined in the DeKAF study. Specifically, this study will examine the link between genetic variants (SNPs), immune suppressant pharmacokinetics, adverse effects, and clinical outcomes. The overall objective is to test the relationship between specific genetic variants of drug metabolizing enzymes, drug transporters, drug targets and biological pathways associated with pharmacokinetics, adverse effects of immunosuppressants, and kidney rejection.