A PILOT STUDY OF TRIGEMINAL NERVE STIMULATION AS A TREATMENT FOR DEPRESSION"

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设1：TNS减轻了轻度至中度重度抑郁症患者的抑郁症状。 具体目标1：比较TNS治疗8周前后的抑郁量表评分。 假设2：TNS耐受良好且安全。 具体目标2a：在TNS之前和期间评估血压和EKG。 具体目标2b：监测TNS期间的不良事件。 假设3：TNS引起双侧丘脑、小脑、边缘系统、下丘脑和延髓的血流改变。 具体目标3：在3名受试者中，比较TNS前后的H215 O PET血流测量值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis 1: TNS reduces depressive symptoms in people with mild to moderate major depressive disorder. Specific Aim 1: Compare depression scale scores before and after 8 weeks of TNS. Hypothesis 2: TNS is well-tolerated and safe. Specific Aim 2a: Assess blood pressure and EKG before and during TNS. Specific Aim 2b: Monitor for adverse events during TNS. Hypothesis 3: TNS causes blood flow changes in the the bilateral thalamus, cerebellum, limbic system, hypothalamus and medulla. Specific Aim 3: In three subjects, compare H215O PET blood flow measurements before and after TNS.