RANDOMIZED CLINICAL TRIAL OF INHALED PGE, IN NEONATAL HYPOXEMIC RESPIRATORY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在研究一种新的治疗严重呼吸问题[呼吸衰竭]的方法--吸入前列腺素，在足月和近期新生儿中的有效性。这项研究还将帮助研究人员了解在大量婴儿中研究这种疗法是否可行。 出生后，为婴儿肺部提供血液的血管立即发生变化，允许全部血液流经肺部。这些变化的发生是因为呼吸伸展了肺部，增加了氧气水平，从而导致血管壁上产生了某些类似激素的物质，称为前列腺素。然后血管放松，让血液自由流动。当婴儿有严重的呼吸问题时，肺部的血管可能会受到挤压，肺部无法获得足够的血液。 15年来，研究人员一直致力于开发医疗方法，以改善患有呼吸衰竭的足月和早产儿的肺部血液流动。松弛血管的药物已经通过静脉给药。这些药物有助于肺部，但也会放松身体其他部位的血管，而这些部位对此无济于事。吸入的一氧化氮只松弛肺部的血管，因为它直接进入肺部。这种治疗非常有帮助，但只能进行有限的时间，需要特殊的设备。20多年来，复制人体自身天然激素前列腺素的静脉药物一直被有效而安全地用于治疗新生儿的某些心脏疾病。前列腺素现在已经在小规模研究中进行了测试，其中PGE1直接进入肺部，结果令人振奋。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is studying the effectiveness of a new treatment for severe breathing problems [respiratory failure], inhaled prostaglandins, in full-term and near-term newborns. This research will also help investigators to know if it is practical to study this therapy in a large number of infants. Immediately after birth, blood vessels which supply blood to the babys lungs go through changes that allow the full amount of blood to flow through the lungs. These changes happen because breathing stretches the lungs and increases the oxygen level, which causes certain hormone-like substances, called prostaglandins, to be made in the blood vessel walls. The blood vessels then relax and allow blood to flow freely. When a baby has severe breathing problems, the blood vessels in the lungs can squeeze tight and the lungs don't get enough blood. Investigators have been working for over 15 years to develop medical treatments to improve blood flow in the lungs of full-term and premature newborns with respiratory failure. Medications which relax blood vessels have been given intravenously. These help the lungs, but also relax blood vessels in other parts of the body where it is not helpful. Inhaled Nitric Oxide relaxes blood vessels in only the lungs because it is given directly into the lungs. This treatment has been very helpful, but can only be given for a limited time and requires special equipment. Intravenous medications that copy the body's own natural hormones, prostaglandins, have been used effectively and safely to treat certain heart conditions in newborns for over 20 years. Prostaglandins have now been tested in small studies where the PGE1 was given directly into the lungs, and the results are promising.