EVALUATING AN ORAL UREA TOLERANCE TEST TO MEASURE OVERALL RENAL FUNCTION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前，使用肾小球滤过率评估肾功能，其在充分预测肾脏疾病水平方面具有局限性。通过开发一种可以更好地评估肾功能的动态工具，慢性肾脏疾病患者的护理将得到改善。口服尿素的肾脏处理及其清除机制可以提供更全面的诊断工具，用于评估肾功能，从而启动适当的治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, kidney function is assessed using the glomerular filtration rate which has limitations in adequately the predicting the level of kidney disease. The care of patients with chronic kidney disease would be improved by developing a dynamic tool that can better assess kidney function. The renal handling of orally ingested urea and the mechanisms of its' clearance can provide a more comprehensive diagnostic tool with which to evaluate kidney function and thereby initiate appropriate treatment.